Results 1 to 10 of about 92,424 (292)

Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency. [PDF]

PLoS ONE, 2010
BACKGROUND: Laminin alpha2 chain mutations cause congenital muscular dystrophy with dysmyelination neuropathy (MDC1A). Previously, we demonstrated that laminin alpha1 chain ameliorates the disease in mice.
Kinga I Gawlik, Mikael Akerlund, Virginie Carmignac, Harri Elamaa, Madeleine Durbeej   +4 more
doaj   +1 more source

Structural mechanism of laminin recognition by integrin

Nature Communications, 2021
Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular ...
Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi   +7 more
doaj   +1 more source

The Laminin Receptors Basal Cell Adhesion Molecule/Lutheran and Integrin α7β1 on Human Hematopoietic Stem Cells

Frontiers in Cell and Developmental Biology, 2021
In the adult organism, hematopoietic stem and progenitor cells (HSPC) reside in the bone marrow (BM) in specialized hematopoietic stem cell niches of which the extracellular matrix (ECM) is an integral component.
Parimala Sonika Godavarthy, Christina B. Walter, Claudia Lengerke, Gerd Klein   +3 more
doaj   +1 more source

Micro-laminin gene therapy can function as an inhibitor of muscle disease in the dyW mouse model of MDC1A

Molecular Therapy: Methods & Clinical Development, 2021
Gene replacement for laminin-α2-deficient congenital muscular dystrophy 1A (MDC1A) is currently not possible using a single adeno-associated virus (AAV) vector due to the large size of the LAMA2 gene.
Davin Packer, Paul T. Martin
doaj   +1 more source

Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics

Frontiers in Molecular Neuroscience, 2020
Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain.
Pamela Barraza-Flores, Christina R. Bates, Ariany Oliveira-Santos, Dean J. Burkin   +3 more
doaj   +1 more source

Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins

Fluids and Barriers of the CNS, 2022
Background Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor interaction or laminin self-assembly ...
Jingsong Ruan, Karen K. McKee, Peter D. Yurchenco, Yao Yao   +3 more
doaj   +1 more source

The importance of laminin at the blood-brain barrier

Neural Regeneration Research, 2023
The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components.
Sebok K Halder, Arjun Sapkota, Richard Milner   +2 more
doaj   +1 more source

β1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival. [PDF]

PLoS ONE, 2012
Extracellular matrix (ECM) integrity in the central nervous system (CNS) is essential for neuronal homeostasis. Signals from the ECM are transmitted to neurons through integrins, a family of cell surface receptors that mediate cell attachment to ECM.
Andrea Rachelle C Santos, Raul G Corredor, Betty Albo Obeso, Ephraim F Trakhtenberg, Ying Wang, Jamie Ponmattam, Galina Dvoriantchikova, Dmitry Ivanov, Valery I Shestopalov, Jeffrey L Goldberg, Mary Elizabeth Fini, Michaela Livia Bajenaru   +11 more
doaj   +1 more source

Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair

Bioactive Materials, 2022
Directional axon regeneration and remyelination are crucial for repair of spinal cord injury (SCI), but existing treatments do not effectively promote those processes.
Bi-Qin Lai, Yu-Rong Bai, Wei-Tao Han, Bao Zhang, Shu Liu, Jia-Hui Sun, Jia-Lin Liu, Ge Li, Xiang Zeng, Ying Ding, Yuan-Huan Ma, Ling Zhang, Zheng-Hong Chen, Jun Wang, Yuan Xiong, Jin-Hua Wu, Qi Quan, Ling-Yan Xing, Hong-Bo Zhang, Yuan-Shan Zeng   +19 more
doaj   +1 more source

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
core   +1 more source