Results 101 to 110 of about 94,523 (291)

Laminin-defined mechanical status modulates retinal pigment epithelium phagocytosis

EMBO Reports
Epithelial cells exhibit strong interconnections that are crucial for tissue mechanical properties. In homeostasis, these properties, termed mechanical homeostasis, depend on the balance between intercellular tension and extracellular matrix (ECM ...
Aleksandra N Kozyrina, Teodora Piskova, Francesca Semeraro, Iris C Doolaar, Taspia Prapty, Tamás Haraszti, Maxime Hubert, Reinhard Windoffer, Rudolf E Leube, Ana-Sunčana Smith, Jacopo Di Russo   +10 more
doaj   +1 more source

Transient outward potassium current and Ca2+ homeostasis in the heart: beyond the action potential

Brazilian Journal of Medical and Biological Research, 2006
Normal central nervous system development relies on accurate intrinsic cellular programs as well as on extrinsic informative cues provided by extracellular molecules.
R.A. Bassani
doaj   +1 more source

Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migration [PDF]

, 2009
Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity.
Akiyama, Al-Ayyoubi, Askari, Bailey, Bass, Bass, Bass, Becerra, Biliran, Blacque, Brown, Cella, Coe, Dollery, Filleur, Filleur, Galis, Gao, Humphries, Huntington, Häyry, Jiang, Khalkhali-Ellis, Laura Wagstaff, Law, Li, Li, Lorna Ravenhill, Luo, McGowen, Mould, Mould, Newby, Ngamkitidechakul, Odero-Marah, Owens, Pemberton, Pemberton, Rosemary Bass, Ross, Schreiner, Schwartz, Sechler, Seftor, Sheng, Sheng, Sheng, Shi, Shi, Smith, Stephens, Vincent Ellis, Yin, Zhang, Zou   +54 more
core   +2 more sources

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

The Not so Good, the Bad and the Ugly: Differential Bacterial Adhesion and Invasion Mediated by Salmonella PagN Allelic Variants

Microorganisms, 2020
While advances in genomic sequencing have highlighted significant strain variability between and within Salmonella serovars, only a few protein variants have been directly related to evolutionary adaptation for survival, such as host specificity or ...
Yanping Wu, Qiaoyun Hu, Ruchika Dehinwal, Alexey V. Rakov, Nicholas Grams, Erin C. Clemens, Jennifer Hofmann, Iruka N. Okeke, Dieter M. Schifferli   +8 more
doaj   +1 more source

Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]

, 2012
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine, Iber, Dagmar, Menshykau, Denis   +2 more
core   +3 more sources

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. [PDF]

, 2003
A considerable body of research indicates that mammary gland branching morphogenesis is dependent, in part, on the extracellular matrix (ECM), ECM-receptors, such as integrins and other ECM receptors, and ECM-degrading enzymes, including matrix ...
A Amour, A Garcia-Gasca, A Lochter, A Lochter, AC Andres, AJ D'Ardenne, AM Belkin, AR Nelson, B Lelongt, BL Hogan, BM Gumbiner, BS Wiseman, C Brisken, C Brisken, CJ Sympson, CS Atwood, CW Daniel, CW Daniel, D Alford, D Alford, DG Stupack, ED Hay, EW Thompson, F Berdichevsky, F Kheradmand, FE Jones, G Bani, G Giannelli, G Shyamala, GB Silberstein, GB Silberstein, GB Silberstein, GB Silberstein, GL Ganser, GW Robinson, GW Robinson, GW Robinson, H Birkedal-Hansen, H Joseph, HJ Hathaway, HY Ha, J Chen, J Lilla, J Muschler, J Russo, J Schlondorff, J Yant, JE Fata, JE Fata, JE Fata, JE Ferguson, JF Wiesen, JJ Wysolmerski, JJ Wysolmerski, JM Bradbury, JM Whitelock, JM Williams, JP Irigoyen, JP Lydon, JP Witty, JT Emerman, K Elenius, K Hotary, K Ito, K Morita, K Wolf, L Hennighausen, LA Rudolph-Owen, LA Rudolph-Owen, LJ van't Veer, LR Lund, M Affolter, M Durbeej, M Egeblad, M Rytomaa, M Simian, MA Arnaout, MD Infeld, MD Sternlicht, MF Horster, MH Barcellos-Hoff, MJ van de Vijver, MM Zutter, MM Zutter, MP Osborne, MR Crowley, MR Warner, MS Wicha, N Koshikawa, N Quarto, NJ Kenney, NK Wessells, OW Petersen, P Bashkin, PR Warfield, PY Desprez, R Lagace, RH Wetzels, RS Talhouk, S Coleman, S Mukherjee, S Selvarajan, S Sinha, S Stahl, SD Banerjee, SD Robinson, SE Baker, SH Barsky, SL Bullock, SM Ellerbroek, T Darribere, T Gudjonsson, T Hayakawa, T Hayakawa, T Hayakawa, TC Klinowska, TC Klinowska, TC Klinowska, TH Vu, TN Seagroves, U Felbor, V Gouon-Evans, V Noe, VM Weaver, W Ruan, W Wang, W Xie, WF Vogel, WF Vogel, WH Yu, WP Bocchinfuso, Y Fukuda, Y Fukuda, Y Hirai, Y Hirai, Y Kadono, Y Nakanishi, YS Kanwar, Z Werb, Z Zhu   +139 more
core   +2 more sources

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source