Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]
, 2010 Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Brockington, M +7 more
core +6 more sources
Role of laminin and cognate receptors in cholangiocarcinoma cell migration
Cell Adhesion & Migration, 2021 Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction.
Kittiya Islam +4 more
doaj +1 more source
Skeletal Muscle, 2017 Background The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle ...
Mariela Natacha González +6 more
doaj +1 more source
A novel monoclonal antibody to human laminin α5 chain strongly inhibits integrin-mediated cell adhesion and migration on laminins 511 and 521. [PDF]
PLoS ONE, 2013 Laminins, a large family of αβγ heterotrimeric proteins mainly found in basement membranes, are strong promoters of adhesion and migration of multiple cell types, such as tumor and immune cells, via several integrin receptors.
Zenebech Wondimu +8 more
doaj +1 more source
Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies
Skeletal Muscle, 2011 Laminin-211 is a cell-adhesion molecule that is strongly expressed in the basement membrane of skeletal muscle. By binding to the cell surface receptors dystroglycan and integrin α7β1, laminin-211 is believed to protect the muscle fiber from damage under
Gawlik Kinga I, Durbeej Madeleine
doaj +1 more source
Receptors that bind to PEDF and their therapeutic roles in retinal diseases
Frontiers in Endocrinology, 2023 Retinal neovascular, neurodegenerative, and inflammatory diseases represented by diabetic retinopathy are the main types of blinding eye disorders that continually cause the increased burden worldwide.
Manhong Xu +3 more
doaj +1 more source
Gene Expression in Amnion-Derived Cells Cultured on Recombinant Laminin 332—A Preliminary Study
Frontiers in Medicine, 2021 Human amniotic cells (hAC) exhibit characteristics of undifferentiated cells and immunomodulatory properties. Recognition of the relationship between amniotic cells and components of the extracellular matrix is an important condition for their ex vivo ...
Katarzyna Skowron-Kandzia +5 more
doaj +1 more source
Laminin receptors on Candida albicans germ tubes [PDF]
Infection and Immunity, 1990 Recent evidence for the role of laminin in cell adhesion and in the pathogenesis of several bacterial infections has led us to investigate the existence of receptors for this extracellular matrix component in Candida albicans. At first, immunofluorescence demonstrated the presence of laminin-binding sites at the surface of germ tubes.
J P, Bouchara +4 more
openaire +2 more sources
Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation. [PDF]
, 2018 Interactions between EphB4 receptor tyrosine kinases and their membrane-bound ephrin-B2 ligands on apposed cells play a regulatory role in neural stem cell differentiation.
Chung, Jean +6 more
core +2 more sources
Laminin Polymerization Induces a Receptor–Cytoskeleton Network [PDF]
The Journal of Cell Biology, 1999 The transition of laminin from a monomeric to a polymerized state is thought to be a crucial step in the development of basement membranes and in the case of skeletal muscle, mutations in laminin can result in severe muscular dystrophies with basement membrane defects.
H, Colognato +2 more
openaire +2 more sources