Results 21 to 30 of about 713,192 (254)

Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. [PDF]

open access: yesPLoS ONE, 2012
Oxidized LDL (ox-LDL) is a key factor in atherogenesis. It is taken up by endothelial cells primarily by ox-LDL receptor-1 (LOX-1). To elucidate transcriptional responses, we performed microarray analysis on human coronary artery endothelial cells ...
Magomed Khaidakov   +8 more
doaj   +1 more source

Macrophage oxidative modification of low density lipoprotein occurs independently of its binding to the low density lipoprotein receptor

open access: yesJournal of Lipid Research, 1996
The oxidative modification of low density lipoproteins (LDL) by arterial wall cells is thought to contribute to atherogenesis. Monocyte/macrophages, among other arterial wall cells, oxidatively modify LDL to a form that is recognized by scavenger ...
R K Tangirala, M J Mol, D Steinberg
doaj   +1 more source

Effects of streptozotocin-induced diabetes on low density lipoprotein receptor expression in rat adipose tissue

open access: yesJournal of Lipid Research, 1996
Low density lipoprotein (LDL) receptors are found in most cells, including adipose cells. LDL receptors are primarily regulated by cellular cholesterol content. Insulin and insulin deficiency have been reported to have varying effects on LDL receptors in
S Swami, C Sztalryd, F B Kraemer
doaj   +1 more source

Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats.

open access: yesJournal of Lipid Research, 1989
The regulation of hepatic cholesterol and lipoprotein metabolism was studied in the ethinyl estradiol-treated rat in which low density lipoprotein (LDL) receptors are increased many fold.
S K Erickson   +4 more
doaj   +1 more source

Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors

open access: yesJournal of Lipid Research, 2004
Endocytosis mediated by both LDL receptors (LDLRs) and transferrin receptors (TfRs) occurs in clathrin-coated pits and requires specific tyrosine-based internalization sequences located in the cytoplasmic domain of these receptors.
Liqin Du, Steven R. Post
doaj   +1 more source

Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages

open access: yesJournal of Lipid Research, 1998
The processes responsible for the uptake of chylomicron remnants by macrophages were investigated using freshly isolated cells from low density lipoprotein (LDL) receptor, very low density lipoprotein (VLDL) receptor and apolipoprotein E knockout mice ...
Yoshio Fujioka   +2 more
doaj   +1 more source

LDL Receptors in Keratinocytes [PDF]

open access: yes, 1992
The presence of sufficient amounts of cholesterol in the epidermis is necessary for proper functioning of plasma membranes in the viable epidermal cell layers and also for the barrier quality of lipid intercellular bilayers of the stratum corneum ...
Vermeer, Bert Jan   +5 more
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

open access: yes, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F.   +3 more
core   +1 more source

Oxidized low-density lipoproteins and their contribution to atherosclerosis [PDF]

open access: yesExploration of Cardiology
The oxidation of lipoproteins has a key role in the development of atherosclerosis, a condition where plaque builds up in artery walls. Research shows that when low-density lipoprotein (LDL) oxidizes, it speeds up atherosclerosis.
Abdullatif Taha Babakr
doaj   +1 more source

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]

open access: yes, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
Herrington, D.M.   +627 more
core   +2 more sources

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