Results 21 to 30 of about 77,479 (303)

Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages

Journal of Lipid Research, 1998
The processes responsible for the uptake of chylomicron remnants by macrophages were investigated using freshly isolated cells from low density lipoprotein (LDL) receptor, very low density lipoprotein (VLDL) receptor and apolipoprotein E knockout mice ...
Yoshio Fujioka, Allen D. Cooper, Loren G. Fong   +2 more
doaj   +1 more source

Oxidized low-density lipoproteins and their contribution to atherosclerosis [PDF]

Exploration of Cardiology
The oxidation of lipoproteins has a key role in the development of atherosclerosis, a condition where plaque builds up in artery walls. Research shows that when low-density lipoprotein (LDL) oxidizes, it speeds up atherosclerosis.
Abdullatif Taha Babakr
doaj   +1 more source

Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.

Journal of Lipid Research, 1987
The rat hepatoma cell line Fu5AH has the unusual property of accumulating massive amounts of cholesteryl ester upon incubation with hypercholesterolemic serum, and especially when incubated with beta-very low density lipoproteins (beta-VLDL) from ...
G Friedman, M E Wernette-Hammond, D Y Hui, R W Mahley, T L Innerarity   +4 more
doaj   +1 more source

Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation

, 2021
Formononetin (FMNT), a flavonoid identified from the Chinese herb Astragalus membranaceus, possesses anti-inflammatory or anti-oxidative properties in different human diseases.
Wenli Zhou (479263), Mingxing Zhao (3707557), Shan Zhang (431282), Baohua Zhang (521406), Zhongwei Hao (11248675), Honglei Li (350859), Naijing Hou (11248678), Cui Jing (11248681), Mingyan Sun (10930392)   +8 more
core   +1 more source

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor[S]

Journal of Lipid Research, 2010
The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular mechanisms have been proposed for the binding of LDL to LDL-R at neutral plasma pH and for its ...
Sha Huang, Lisa Henry, Yiu Kee Ho, Henry J. Pownall, Gabby Rudenko   +4 more
doaj   +1 more source

Increased uptake of α-hydroxy aldehyde-modified low density lipoprotein by macrophage scavenger receptors

Journal of Lipid Research, 2000
Reactive aldehydes can be formed during the oxidation of lipids, glucose, and amino acids and during the nonenzymatic glycation of proteins. Low density lipoprotein (LDL) modified with malondialdehyde are taken up by scavenger receptors on macrophages ...
Mitsunobu Kawamura, Jay W. Heinecke, Alan Chait   +2 more
doaj   +1 more source

Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors

Journal of Lipid Research, 2005
Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in
David R. Greaves, Siamon Gordon
doaj   +1 more source

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

, 2004
Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Owen, JS, Everett, D M, Murdock, P R, Everett, DM, Murdock, PR, Owen, J S, Dingwall, C, Thilakawardhana, S   +7 more
core   +1 more source

Compensated endocytosis of LDL by hamster cells co-expressing the two distinct mutant LDL receptors defective in endocytosis and ligand binding

Journal of Lipid Research, 1999
The low density lipoprotein receptor (LDLR) regulates the plasma cholesterol level by mediating endocytosis of LDL. We established stable hamster cell lines expressing two LDLRs with distinct functional defects, i.e., endocytosis and ligand binding.
Hiroyuki Yoshida, Masayuki Yokode, Akitsugu Yamamoto, Ryuichi Masaki, Toshinori Murayama, Hisanori Horiuchi, Toru Kita   +6 more
doaj   +1 more source

Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells.

Journal of Lipid Research, 1991
Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2).
RI Grove, C Mazzucco, N Allegretto, PA Kiener, G Spitalny, SF Radka, M Shoyab, M Antonaccio, GA Warr   +8 more
doaj   +1 more source