Results 11 to 20 of about 77,479 (303)

Dopamine D1-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL

Cellular Physiology and Biochemistry, 2016
Background/Aims: Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, a key physiological process which leads to atherosclerosis.
Yonggang Yao, Di Yang, Yu Han, Wei Wang, Na Wang, Jian Yang, Chunyu Zeng   +6 more
doaj   +2 more sources

LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery [PDF]

Journal of Lipid Research, 2023
Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear.
Shobini Jayaraman, Antonio Pérez, Inka Miñambres, Jose Luis Sánchez-Quesada, Olga Gursky   +4 more
doaj   +2 more sources

Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer

Brazilian Journal of Medical and Biological Research, 2012
Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors.
L.A. Pires, R. Hegg, F.R. Freitas, E.R. Tavares, C.P. Almeida, E.C. Baracat, R.C. Maranhão   +6 more
doaj   +4 more sources

Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages [PDF]

Cells, 2020
Electronegative low-density lipoprotein (LDL) (LDL(−)), a modified LDL that is present in blood and exerts atherogenic effects on endothelial cells and monocytes.
Núria Puig, Lara Montolio, Pol Camps-Renom, Laia Navarra, Francesc Jiménez-Altayó, Elena Jiménez-Xarrié, Jose Luis Sánchez-Quesada, Sonia Benitez   +7 more
doaj   +2 more sources

Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes [PDF]

, 2008
Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease.
B. O’Malley, J. A. D. Wattis, Panovska, J., Byrne, H.M., Jackson, K.G., H. Blackburn, Wattis, JA, H. M. Byrne, L. Pickersgill, O'Malley, B, Panovska, J, Wattis, J.A.D., Pickersgill, L, Pickersgill, L., Blackburn, H, Byrne, HM, Byrne, Helen, K. G. Jackson, Wattis, JAD, O'Malley, B., Blackburn, H., Jackson, KG, J. Panovska   +22 more
core   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats.

Journal of Lipid Research, 1989
The regulation of hepatic cholesterol and lipoprotein metabolism was studied in the ethinyl estradiol-treated rat in which low density lipoprotein (LDL) receptors are increased many fold.
S K Erickson, S Jaeckle, S R Lear, S M Brady, R J Havel   +4 more
doaj   +1 more source

Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors

Journal of Lipid Research, 2004
Endocytosis mediated by both LDL receptors (LDLRs) and transferrin receptors (TfRs) occurs in clathrin-coated pits and requires specific tyrosine-based internalization sequences located in the cytoplasmic domain of these receptors.
Liqin Du, Steven R. Post
doaj   +1 more source

LDL-receptor mutations in Europe [PDF]

Human Mutation, 2004
Familial hypercholesterolemia (FH) is a clinical definition for a remarkable increase of cholesterol serum concentration, presence of xanthomas, and an autosomal dominant trait of either increased serum cholesterol or premature coronary artery disease (CAD). The identification of the low-density lipoprotein (LDL)-receptor (LDLR) as the underlying cause
George V Z, Dedoussis, Hartmut, Schmidt, Janine, Genschel   +2 more
openaire   +2 more sources