Results 11 to 20 of about 73,504 (258)
LDL-receptor mutations in Europe [PDF]
Human Mutation, 2004 Familial hypercholesterolemia (FH) is a clinical definition for a remarkable increase of cholesterol serum concentration, presence of xanthomas, and an autosomal dominant trait of either increased serum cholesterol or premature coronary artery disease (CAD). The identification of the low-density lipoprotein (LDL)-receptor (LDLR) as the underlying cause
George V Z, Dedoussis +2 more
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Journal of Lipid Research, 2004 Endocytosis mediated by both LDL receptors (LDLRs) and transferrin receptors (TfRs) occurs in clathrin-coated pits and requires specific tyrosine-based internalization sequences located in the cytoplasmic domain of these receptors.
Liqin Du, Steven R. Post
doaj +1 more source
Journal of Lipid Research, 1998 The processes responsible for the uptake of chylomicron remnants by macrophages were investigated using freshly isolated cells from low density lipoprotein (LDL) receptor, very low density lipoprotein (VLDL) receptor and apolipoprotein E knockout mice ...
Yoshio Fujioka +2 more
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Dopamine D1-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL
Cellular Physiology and Biochemistry, 2016 Background/Aims: Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, a key physiological process which leads to atherosclerosis.
Yonggang Yao +6 more
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Oxidized low-density lipoproteins and their contribution to atherosclerosis [PDF]
Exploration of CardiologyThe oxidation of lipoproteins has a key role in the development of atherosclerosis, a condition where plaque builds up in artery walls. Research shows that when low-density lipoprotein (LDL) oxidizes, it speeds up atherosclerosis.
Abdullatif Taha Babakr
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Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.
Journal of Lipid Research, 1987 The rat hepatoma cell line Fu5AH has the unusual property of accumulating massive amounts of cholesteryl ester upon incubation with hypercholesterolemic serum, and especially when incubated with beta-very low density lipoproteins (beta-VLDL) from ...
G Friedman +4 more
doaj +1 more source
Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor[S]
Journal of Lipid Research, 2010 The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular mechanisms have been proposed for the binding of LDL to LDL-R at neutral plasma pH and for its ...
Sha Huang +4 more
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Journal of Lipid Research, 2023 Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear.
Shobini Jayaraman +4 more
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Human Coronary Smooth Muscle Cells Internalize Versican-Modified LDL Through LDL Receptor–Related Protein and LDL Receptors [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 Versican-like proteoglycans are the main component of the intimal extracellular matrix interacting with low density lipoprotein (LDL). The aim of this study has been to investigate the receptors involved in versican-modified LDL uptake by human vascular smooth muscle cells (VSMCs). We have found that versican-LDL interaction leads to the following: (1)
Llorente-Cortés, Vicenta +4 more
openaire +3 more sources
Journal of Lipid Research, 2000 Reactive aldehydes can be formed during the oxidation of lipids, glucose, and amino acids and during the nonenzymatic glycation of proteins. Low density lipoprotein (LDL) modified with malondialdehyde are taken up by scavenger receptors on macrophages ...
Mitsunobu Kawamura +2 more
doaj +1 more source