Results 31 to 40 of about 713,192 (254)

Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.

Journal of Lipid Research, 1987
The rat hepatoma cell line Fu5AH has the unusual property of accumulating massive amounts of cholesteryl ester upon incubation with hypercholesterolemic serum, and especially when incubated with beta-very low density lipoproteins (beta-VLDL) from ...
G Friedman, M E Wernette-Hammond, D Y Hui, R W Mahley, T L Innerarity   +4 more
doaj   +1 more source

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor[S]

Journal of Lipid Research, 2010
The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular mechanisms have been proposed for the binding of LDL to LDL-R at neutral plasma pH and for its ...
Sha Huang, Lisa Henry, Yiu Kee Ho, Henry J. Pownall, Gabby Rudenko   +4 more
doaj   +1 more source

LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery

Journal of Lipid Research, 2023
Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear.
Shobini Jayaraman, Antonio Pérez, Inka Miñambres, Jose Luis Sánchez-Quesada, Olga Gursky   +4 more
doaj   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
core   +1 more source

Increased uptake of α-hydroxy aldehyde-modified low density lipoprotein by macrophage scavenger receptors

Journal of Lipid Research, 2000
Reactive aldehydes can be formed during the oxidation of lipids, glucose, and amino acids and during the nonenzymatic glycation of proteins. Low density lipoprotein (LDL) modified with malondialdehyde are taken up by scavenger receptors on macrophages ...
Mitsunobu Kawamura, Jay W. Heinecke, Alan Chait   +2 more
doaj   +1 more source

Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors

Journal of Lipid Research, 2005
Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in
David R. Greaves, Siamon Gordon
doaj   +1 more source

Compensated endocytosis of LDL by hamster cells co-expressing the two distinct mutant LDL receptors defective in endocytosis and ligand binding

Journal of Lipid Research, 1999
The low density lipoprotein receptor (LDLR) regulates the plasma cholesterol level by mediating endocytosis of LDL. We established stable hamster cell lines expressing two LDLRs with distinct functional defects, i.e., endocytosis and ligand binding.
Hiroyuki Yoshida, Masayuki Yokode, Akitsugu Yamamoto, Ryuichi Masaki, Toshinori Murayama, Hisanori Horiuchi, Toru Kita   +6 more
doaj   +1 more source

Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells.

Journal of Lipid Research, 1991
Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2).
RI Grove, C Mazzucco, N Allegretto, PA Kiener, G Spitalny, SF Radka, M Shoyab, M Antonaccio, GA Warr   +8 more
doaj   +1 more source

LDL-C target attainment in the total cohort and stratified by risk as observed and simulated.

, 2022
LDL-C concentrations are given as median (interquartile range). LDL-C: Low-density lipoprotein cholesterol. LLT: Lipid-lowering therapy.
Aikaterini Bilitou (5785471), Ulrich Laufs (360751), Christian Becker (49615), Julius L. Katzmann (10960479)   +3 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source