Results 51 to 60 of about 77,479 (303)
S-nitrosylation of ARH is required for LDL uptake by the LDL receptor [PDF]
Journal of Lipid Research, 2013 The LDL receptor (LDLR) relies upon endocytic adaptor proteins for internalization of lipoproteins. The results of this study show that the LDLR adaptor autosomal recessive hypercholesterolemia protein (ARH) requires nitric oxide to support LDL uptake.
Zhenze Zhao +5 more
openaire +3 more sources
Mecanismos moleculares que relacionam a hipercolesterolemia familiar à doença de Alzheimer [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2015.A hipercolesterolemia familiar é uma doença do metabolismo das lipoproteínas causada por anormalidades ...
Oliveira, Jade de
core
Redirected targeting of LDL to human monocyte Fc gamma receptors with bispecific antibodies.
, 1992 Recent studies indicate that low density lipoprotein (LDL)-immune complexes consisting of anti-LDL antibodies bound to LDL may contribute to macrophage foam cell development by uptake through immunoglobulin G (IgG) Fc receptors.
P M Morganelli +3 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Measurement of total hepatic low density lipoprotein receptor levels in the hamster.
Journal of Lipid Research, 1993 The ability to measure the total concentration of low density lipoprotein (LDL) receptors in hepatic tissues is of crucial importance to understanding changes in hepatic cholesterol metabolism.
PG Cosgrove, BJ Gaynor, HJ Harwood, Jr
doaj +1 more source
Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]
, 2002 Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Pavenstadt, H. +13 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Plasma PCSK9 preferentially reduces liver LDL receptors in mice*
Journal of Lipid Research, 2008 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein. Gain-of-function mutations in PCSK9 cause hypercholesterolemia, and loss-of-function mutations result in lower ...
Aldo Grefhorst +3 more
doaj +1 more source
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor [PDF]
Journal of Lipid Research, 2007 LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear. Taking into account the importance of the endothelial barrier for lipoprotein uptake, in vitro studies with primary aortic endothelial cells from wild-type and low density ...
Britta Loeffler +6 more
openaire +3 more sources
MRI Detection of Tumor Cells by Targeting LDL Receptors with Gd-loaded LDL Particles
, 2007 Gd-DO3A-diph and Gd-AAZTAC17 are lipophilic magnetic resonance imaging (MRI) agents that display high affinity for low-density lipoprotein (LDL) particles.
ALBERTI D +8 more
core +1 more source