Results 11 to 20 of about 2,358,182 (190)
Journal of Medicine and Life, 2021 Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes.
Hany Akeel Al-hussaniy +2 more
semanticscholar +1 more source
Food for Thought: Leptin and Hippocampal Synaptic Function
Frontiers in Pharmacology, 2022 It is well documented that the endocrine hormone, leptin controls energy homeostasis by providing key signals to specific hypothalamic nuclei. However, our knowledge of leptin’s central actions has advanced considerably over the last 20 years, with the ...
Jenni Harvey
doaj +1 more source
Leptin and leptin receptor expression in asthma [PDF]
Journal of Allergy and Clinical Immunology, 2009 The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina Bruno +9 more
openaire +3 more sources
Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus
eLife, 2020 The nucleus of the solitary tract (NTS) is critical for the central integration of signals from visceral organs and contains preproglucagon (PPG) neurons, which express leptin receptors in the mouse and send direct projections to the paraventricular ...
Jessica E Biddinger +3 more
doaj +1 more source
Cancer Medicine, 2020 Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers worldwide. Despite the growing evidence associating obesity and adipokines, particularly leptin and its receptors, with cancer development and progression, it is still a ...
Hala Fawzy Mohamed Kamel +2 more
doaj +1 more source
Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells. [PDF]
PLoS ONE, 2016 Obesity is a significant risk factor for certain cancers, including hepatocellular carcinoma (HCC). Leptin, a hormone secreted by white adipose tissue, precipitates HCC development. Epidemiology data show that men have a much higher incidence of HCC than
Minqian Shen, Haifei Shi
doaj +1 more source
The Importance of Leptin to Reproduction.
Endocrinology, 2020 A healthy nutritional state is required for all aspects of reproduction and signaled by the adipokine leptin. Leptin acts in a relatively narrow concentration range; too much or too little will compromise fertility.
G. Childs +3 more
semanticscholar +1 more source
On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin [PDF]
Frontiers in Endocrinology, 2017 Over a decade passed between Friedman's discovery of the mammalian leptin gene (1) and its cloning in fish (2) and amphibians (3). Since 2005, the concept of gene synteny conservation (vs. gene sequence homology) was instrumental in identifying leptin genes in dozens of species, and we now have leptin genes from all major classes of vertebrates.
Matthew Tuttle +4 more
openaire +2 more sources
Journal of applied physiology, 2017 In obesity, leptin receptors (OBR) and leptin signaling in skeletal muscle are downregulated. To determine whether OBR and leptin signaling are upregulated with a severe energy deficit, 15 overweight men were assessed before the intervention (PRE), after
I. Perez‐Suarez +8 more
semanticscholar +1 more source
Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation [PDF]
Diabetes, 2002 A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor (sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group 1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), and 10 individuals with a mutation in the ObR gene, leading to production of a ...
Najiba Lahlou +6 more
openaire +3 more sources