Results 31 to 40 of about 2,401,298 (264)

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

International Journal of Obesity, 2017
Objective:Resistance at the brain receptors for leptin and insulin has been associated with increased feeding, obesity and cognitive impairments. The causal agent for central resistance is unknown but could be derived from the blood.
W. A. Banks, S. Farr, Therese S Salameh, M. Niehoff, E. Rhea, J. Morley, A. Hanson, K. Hansen, S. Craft   +8 more
semanticscholar   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

Molecular Metabolism, 2015
Aims/hypothesis: The adipose tissue-derived hormone leptin plays an important role in the maintenance of body weight and glucose homeostasis. Leptin mediates its effects by interaction with leptin receptors (LepRb), which are highly expressed in the ...
Helen Soedling, David J. Hodson, Alice E. Adrianssens, Fiona M. Gribble, Frank Reimann, Stefan Trapp, Guy A. Rutter   +6 more
doaj   +1 more source

Leptin in the Commissural Nucleus of the Tractus Solitarius (cNTS) and Anoxic Stimulus in the Carotid Body Chemoreceptors Increases cNTS Leptin Signaling Receptor and Brain Glucose Retention in Rats

Medicina, 2022
Background and Objectives: The commissural nucleus of the tractus solitarius (cNTS) not only responds to glucose levels directly, but also receives afferent signals from the liver, and from the carotid chemoreceptors (CChR).
Mónica Lemus, Cynthia Mojarro, Sergio Montero, Mario Ramírez-Flores, José Torres-Magallanes, Adrián Maturano-Melgoza, Elena Roces de Álvarez-Buylla   +6 more
doaj   +1 more source

Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta

Clinical Epigenetics, 2019
It is well established that obesity is associated with dysregulation of the ratio between the two major adipokines leptin and adiponectin. Furthermore, it was recently reported that maternal obesity has a significant impact on placental development ...
P. Nogues, E. Dos Santos, H. Jammes, P. Berveiller, L. Arnould, F. Vialard, M. Dieudonné   +6 more
semanticscholar   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Leptin into the rostral ventral lateral medulla (RVLM) augments renal sympathetic nerve activity and blood pressure

Frontiers in Neuroscience, 2014
Leptin is a hormone released from adipose tissue. While this hormone normally acts to reduce feeding behavior and increase energy expenditure, in obesity, resistance to these effects occurs even though the hormone is released in large amounts. Although
Maria J Barnes, David Harry McDougal
doaj   +1 more source

Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]

PLoS ONE, 2012
Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su, Lin Jiang, Christin Carter-Su, Liangyou Rui   +3 more
doaj   +1 more source

Leptin receptors

European Journal of Medical Research, 2010
Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene.
E. Górska, K. Popko, A. Stelmaszczyk-Emmel, O. Ciepiela, A. Kucharska, M. Wąsik   +5 more
semanticscholar   +1 more source