Results 31 to 40 of about 90,005 (196)

Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation. [PDF]

PLoS ONE, 2013
Leptin receptors are abundant in human skeletal muscle, but the role of leptin in muscle growth, development and aging is not well understood. Here we utilized a novel mouse model lacking all functional leptin receptor isoforms (POUND mouse, Lepr(db/lb))
Phonepasong Arounleut, Matthew Bowser, Sunil Upadhyay, Xing-Ming Shi, Sadanand Fulzele, Maribeth H Johnson, Alexis M Stranahan, William D Hill, Carlos M Isales, Mark W Hamrick   +9 more
doaj   +1 more source

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Bee K. Tan, Chen, Clifford J. Bailey, Cohen, Dielen, Eckel, Fried, Frühbeck, Fukuhara, Haider, Han, Harpal S. Randeva, Havel, Hector, Hendrik Lehnert, James Brown, Jing Chen, Kellerer, Kershaw, Kim, Krzyzanowska, Mahabir, Manjunath Ramanjaneya, Murakami, Otero, Pagano, Pfaffl, Raghu Adya, Sahai, Sandeep, Shimomura, Tan, Van Heek, Vinod Menon, Yang   +34 more
core   +2 more sources

Leptin and Soluble Leptin Receptor in Follicular Fluid [PDF]

Journal of Assisted Reproduction and Genetics, 2003
Previous studies suggest that follicular fluid leptin levels predict successful assisted reproduction. The relationship between intrafollicular leptin and the soluble leptin receptor, ovarian hormones, and oocyte quality was examined to determine potential factors contributing to this finding.Follicular fluid leptin, soluble leptin receptor, hormones ...
Kathleen Heist, Corrine K. Welt, Christos S. Mantzoros, Alan L. Schneyer   +3 more
openaire   +3 more sources

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi   +4 more
doaj   +1 more source

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]

, 2019
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core   +1 more source

The pharmacology and function of receptors for short-chain fatty acids [PDF]

, 2015
Despite some blockbuster G protein–coupled receptor (GPCR) drugs, only a small fraction (∼15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry.
Bolognini, Daniele, Milligan, Graeme, Moss, Catherine E., Tobin, Andrew B.   +3 more
core   +1 more source

Kinetics of Leptin Binding to the Q223R Leptin Receptor

PLoS ONE, 2014
Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans, Naylor, Caitlin, Zabeau, Lennart, Tavernier, Jan, Petri, William A, Jr, Marie, Chelsea   +5 more
openaire   +4 more sources

The Effects of Leptin on Glial Cells in Neurological Diseases

Frontiers in Neuroscience, 2019
It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice.
Yuki Fujita, Yuki Fujita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita   +5 more
doaj   +1 more source

Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

Frontiers in Cell and Developmental Biology, 2021
In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying ...
Anna Acheva, Tytti Kärki, Niccole Schaible, Ramaswamy Krishnan, Sari Tojkander   +4 more
doaj   +1 more source

CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

Molecular Metabolism, 2014
Metabolic flexibility allows rapid adaptation to dietary change, however, little is known about the CNS mechanisms regulating this process. Neurons in the hypothalamic ventromedial nucleus (VMN) participate in energy balance and are the target of the ...
Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota   +12 more
doaj   +1 more source