Results 1 to 10 of about 2,558,356 (334)

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus. [PDF]

PLoS Pathogens, 2016
Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their interplay are not fully understood. In this study, deficiency of both SR-
Satomi Yamamoto, Takasuke Fukuhara, Chikako Ono, Kentaro Uemura, Yukako Kawachi, Mai Shiokawa, Hiroyuki Mori, Masami Wada, Ryoichi Shima, Toru Okamoto, Nobuhiko Hiraga, Ryosuke Suzuki, Kazuaki Chayama, Takaji Wakita, Yoshiharu Matsuura   +14 more
doaj   +2 more sources

Reelin Is a Ligand for Lipoprotein Receptors [PDF]

Neuron, 1999
A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 ...
Michael Sheldon, Gabriella D'Arcangelo, Ramin Homayouni, Dennis S. Rice, Lakhu Keshvara, Tom Curran   +5 more
openaire   +4 more sources

Lipoprotein receptor signalling in atherosclerosis [PDF]

Cardiovascular Research, 2019
AbstractThe founding member of the lipoprotein receptor family, low-density lipoprotein receptor (LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis of LDL particles and regulation of cholesterol homeostasis. Since the discovery of the LDLR, many other structurally and functionally related receptors have been ...
C. Mineo
openaire   +4 more sources

Functions of lipoprotein receptors in neurons [PDF]

Journal of Lipid Research, 2004
The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions.
Uwe Beffert, Peggy C. Stolt, Joachim Herz   +2 more
doaj   +4 more sources

Expanding functions of lipoprotein receptors

Journal of Lipid Research, 2009
Lipoprotein receptors are evolutionarily ancient proteins that are expressed on the surface of many cell types. Beginning with the appearance of the first primitive multicellular organisms, several structurally and functionally distinct families of ...
Joachim Herz, Ying Chen, Irene Masiulis, Li Zhou   +3 more
doaj   +3 more sources

Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity

Cells, 2021
The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is associated with the formation of lipid-rich membranous organelles and infectious particle assembly ...
Francisco J. Zapatero-Belinchón, Rina Ötjengerdes, Julie Sheldon, Benjamin Schulte, Belén Carriquí-Madroñal, Graham Brogden, Laura M. Arroyo-Fernández, Florian W. R. Vondran, Benjamin Maasoumy, Thomas von Hahn, Gisa Gerold   +10 more
doaj   +1 more source

Patched, the receptor of Hedgehog, is a lipoprotein receptor [PDF]

Proceedings of the National Academy of Sciences, 2008
The Hedgehog (Hh) family of secreted signaling proteins has a broad variety of functions during metazoan development and implications in human disease. Despite Hh being modified by two lipophilic adducts, Hh migrates far from its site of synthesis and programs cellular outcomes depending on its local concentrations.
Callejo, Ainhoa, Culi, Joaquim, Guerrero Vega, Isabel   +2 more
openaire   +4 more sources

Staphylococcus aureus increases Prostaglandin E2 secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways

Frontiers in Microbiology, 2023
IntroductionIn clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been regarded as essential for host defense against S. aureus.
Kai Zhang, Kai Zhang, Yan Jia, Yan Jia, Yinghong Qian, Xueying Jiang, Xueying Jiang, Shuangyi Zhang, Shuangyi Zhang, Bo Liu, Bo Liu, Jinshan Cao, Jinshan Cao, Yongli Song, Wei Mao, Wei Mao   +15 more
doaj   +1 more source

Scavenger receptor-BI is a receptor for lipoprotein(a) [PDF]

Journal of Lipid Research, 2013
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ligand. Stable cell lines (HEK293 and HeLa) expressing human SR-BI were incubated with protein- or lipid-
Roger Kurlander, Marcelo Amar, Xiao Ping Yang, Tatyana G. Vishnyakova, Boris L. Vaisman, Alan T. Remaley, Alexander V. Bocharov, Amy P. Patterson, Lewis C. Becker, Lita A. Freeman   +9 more
openaire   +4 more sources

Functional Roles of the Interaction of APP and Lipoprotein Receptors

Frontiers in Molecular Neuroscience, 2017
The biological fates of the key initiator of Alzheimer’s disease (AD), the amyloid precursor protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) receptor-related proteins (LRPs) and their molecular roles in the ...
Theresa Pohlkamp, Catherine R. Wasser, J. Herz   +2 more
semanticscholar   +1 more source