Results 21 to 30 of about 127,504 (263)

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer’s disease

Frontiers in Physiology, 2012
Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes ...
Carlos eSpuch, Saida eOrtolano, Carmen eNavarro   +2 more
doaj   +1 more source

Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake[S]

Journal of Lipid Research, 2019
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the LDL receptor (LDLR) for degradation, increasing plasma LDL and, consequently, cardiovascular risk.
Adri M. Galvan, John S. Chorba
doaj   +1 more source

Reelin Is a Ligand for Lipoprotein Receptors [PDF]

Neuron, 1999
A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 ...
D'Arcangelo, Gabriella, Homayouni, Ramin, Keshvara, Lakhu, Rice, Dennis S, Sheldon, Michael, Curran, Tom   +5 more
openaire   +2 more sources

Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice

Journal of Lipid Research, 2005
The very low density lipoprotein receptor (VLDLR), low density lipoprotein receptor (LDLR), and low density lipoprotein receptor-related protein (LRP) are the three main apolipoprotein E-recognizing endocytic receptors involved in the clearance of ...
Sonia M. S. Espirito Santo, Patrick C.N. Rensen, Jeltje R. Goudriaan, André Bensadoun, Niels Bovenschen, Peter J. Voshol, Louis M. Havekes, Bart J.M. van Vlijmen   +7 more
doaj   +1 more source

Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor

Journal of Lipid Research, 2007
Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic, Zhi Hua Huang, De Sheng Gu, Michael K. Altenburg, Nobuyo Maeda, Theodore Mazzone   +5 more
doaj   +1 more source

Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.

Journal of Lipid Research, 1987
The rat hepatoma cell line Fu5AH has the unusual property of accumulating massive amounts of cholesteryl ester upon incubation with hypercholesterolemic serum, and especially when incubated with beta-very low density lipoproteins (beta-VLDL) from ...
G Friedman, M E Wernette-Hammond, D Y Hui, R W Mahley, T L Innerarity   +4 more
doaj   +1 more source

Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture

Journal of Lipid Research, 1998
In this study the effect of lipoprotein lipase (LPL) on the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by hepatic cells was investigated.
Franz Rinninger, Tatjana Kaiser, W. Alexander Mann, Nicolette Meyer, Heiner Greten, Ulrike Beisiegel   +5 more
doaj   +1 more source

LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. [PDF]

PLoS ONE, 2015
Within the circulation, cholesterol is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors.
Anna P Lillis, Selen Catania Muratoglu, Dianaly T Au, Mary Migliorini, Mi-Jeong Lee, Susan K Fried, Irina Mikhailenko, Dudley K Strickland   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effects of the Variants of Activin Receptor-like Kinase-1 and 2 on the Lipid Profile of Patients with Coronary Heart Disease

İstanbul Medical Journal, 2020
Introduction:Coronary heart disease (CHD) due to atherosclerosis is a multifactorial disease with high morbidity caused by interaction of various genetic and environmental factors.
Ayşegül Başak Akadam Teker, Erhan Teker, Hülya Yılmaz Aydoğan   +2 more
doaj   +1 more source