Results 111 to 120 of about 103,596 (266)

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Differential effects of interferon-γ on metabolism of lipoprotein immune complexes mediated by specific human macrophage Fcγ receptors

Journal of Lipid Research, 2000
: The objectives were to determine whether there are differences in the mechanisms of lipoprotein metabolism associated with different FcγRs and how metabolism associated with FcγRs compares to that mediated by scavenger receptors (SRA).
Peter M. Morganelli, Susan M. Kennedy, Teresa I. Mitchell   +2 more
doaj  

Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins

Advanced Science, EarlyView.
Small organic molecules that are anchored into the lipid bilayer of a mammalian cell and have an exofacial recognition ligand can act as artificial internalizing receptors. These receptors are an efficacious tool to selectively capture and internalize cognate antibodies from the extracellular environment in a protein‐specific manner.
Ane B. Søgaard, Rikke Fabech Hansson, Mikkel Høj Nielsen, Alexander N. Zelikin   +3 more
wiley   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

A Multifunctional Probe for Visualization of the Nanoscale Distribution of Cholesterol in Cells by Expansion Microscopy

Aggregate, EarlyView.
We develop an azido‐ and amino‐functionalized cholesterol probe that can be efficiently fixed and used for expansion microscopy (ExM). This cholesterol probe enables nanoscale tracking of cholesterol distribution dynamics in the endocytic pathway. Combining 10‐fold robust ExM and structured illumination microscopy allows us to resolve cholesterol ...
Gang Wen, Dominic A. Helmerich, Lisa Behringer‐Pließ, Markus Sauer   +3 more
wiley   +1 more source

Spatiotemporal Super‐Resolution Imaging of Lipid Metabolism Dynamics in Physiological/Pathological Conditions

Angewandte Chemie, EarlyView.
A novel polarity‐sensitive fluorescent probe was developed for the selective targeting of lipid droplets, enabling precise visualization and quantification of lipid metabolism disorders using an integrated STED‐FLIM platform. This probe allows accurate monitoring of lipid metabolism in cellular and pathological contexts, such as atherosclerosis ...
Shixian Cao, Qihang Ding, Caixia Sun, Borbala Codogno, Zhiqiang Liu, Xiaoqiang Yu, Jong Seung Kim, Kang‐Nan Wang   +7 more
wiley   +2 more sources

Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins. [PDF]

Front Immunol
Araujo G, Valencia LM, Martin-Ozimek A, Soto Y, Proctor SD.   +4 more
europepmc   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
wiley   +1 more source

AFM reveals differential effects of acidification on LDL- and oxidized LDL-receptor interactions: biomechanical implications in atherogenesis. [PDF]

Cell Mol Biol Lett
Wang K, Sun C, Zhuang H, Jiang XC, Chen Y.   +4 more
europepmc   +1 more source

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

Animal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md. Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md. Hemayet Hossain, Safaet Alam   +9 more
wiley   +1 more source