Results 241 to 250 of about 2,667,642 (350)

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

Crossing the Blood-Brain Barrier: Innovations in Receptor- and Transporter-Mediated Transcytosis Strategies. [PDF]

Pharmaceutics
Ding L, Kshirsagar P, Agrawal P, Murry DJ.   +3 more
europepmc   +1 more source

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

The cardioprotective role of the G protein-coupled receptor FFAR4 in atherosclerosis is independent of macrophage foam cell regulation. [PDF]

J Biol Chem
Stuttgen GM, Ring CJ, Guda VS, Valdivia Esparza GK, Sahoo D.   +4 more
europepmc   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Mediterranean Diet Modulates Gene Expression of Cholesterol Efflux Receptors in High-Risk Cardiovascular Patients. [PDF]

Mol Nutr Food Res
Hernando-Redondo J, Hernáez Á, Sanllorente A, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Arós F, Martínez-González MÁ, Subirana I, Muñoz-Aguayo D, Malcampo M, Serra-Majem L, Romaguera D, Lapetra J, Ros E, Tinahones F, Lamuela-Raventós RM, Gómez-Gracia E, Fitó M, Castañer O.   +20 more
europepmc   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Exploring hypothyroidism's effects on lipid profiles: Evidence of metabolic consequences in subclinical disease. [PDF]

Saudi Med J
Alnahdi HM.
europepmc   +1 more source

LC‐DAD‐MSn and HR‐LC‐QTOF Analysis of Ziziphus budhensis Leaves and Evaluation of Their In Vitro and In Vivo Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Ziziphus budhensis Bhattarai & M.L. Pathak is a specie described in 2015 in Nepal poorly studied for its phytochemical composition and possible bioactivities. In this study, six extracts were obtained from Z. budhensis leaves using ultrasound assisted extraction with solvents in increasing polarity namely hexane, dichloromethane, chloroform ...
Samjhana Bharati, Binita Maharjan, Timila Shrestha, Shyam Sharan Shrestha, Stefania Sut, Hari Prasad Devkota, Ram Lal Swagat Shrestha, Stefano Dall'Acqua   +7 more
wiley   +1 more source

Platelet reactivity to adenosine diphosphate and <i>CYP2C19</i> genotypes are linked with carotid plaques and may predict carotid plaque stability in acute ischemic stroke patients. [PDF]

Neurosciences (Riyadh)
Shi H, Tang M, Wang T, Yang L, Lai X, Chen Y, Diao F, Chen X, Zuo J, Xu J, Zhong G, Dong Y.   +11 more
europepmc   +1 more source