Results 31 to 40 of about 2,588,518 (167)

Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia.

New England Journal of Medicine, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
D. Bilheimer, J. Goldstein, S. Grundy, T. Starzl, Michael S. Brown   +4 more
semanticscholar   +1 more source

Isolation and characterization of two distinct species of human very low density lipoproteins lacking apolipoprotein E

Journal of Lipid Research, 1996
We have isolated two fractions of very low density lipoprotein particles in human plasma that lack apolipoprotein (apo) E by combined anti-apoE and heparin affinity chromatography of whole plasma followed by ultracentrifugation.
E Campos, S Jäckle, G Chi Chen, R J Havel   +3 more
doaj  

Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease

Viruses, 2013
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Thomas F. Baumert, Catherine Schuster, Mathieu Lefevre, Mohamed Lamine Hafirassou, Daniel J. Felmlee   +4 more
doaj   +1 more source

Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents.

Proceedings of the National Academy of Sciences of the United States of America, 2005
We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normal lipoprotein receptors to other selected cancer-associated ...
G. Zheng, Juan Chen, Hui Li, J. Glickson
semanticscholar   +1 more source

Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype

Journal of Lipid Research, 2013
Atherosis of spiral arteries in uteroplacental beds from preeclamptic women resemble those of atherosclerosis, characterized by increased plasma lipids and lipoproteins. We hypothesized that: 1) lipoprotein receptors/transporters in the placenta would be
Marta R. Hentschke, Carlos E. Poli-de-Figueiredo, Bartira E. Pinheiro da Costa, Lesia O. Kurlak, Paula J. Williams, Hiten D. Mistry   +5 more
doaj  

Ganglioside embedded in reconstituted lipoprotein binds cholera toxin with elevated affinity[S]

Journal of Lipid Research, 2010
The ability to exogenously present cell-surface receptors in high-affinity conformations in a synthetic system offers an opportunity to provide host cells with protection from pathogenic toxins.
Daniel A. Bricarello, Emily J. Mills, Jitka Petrlova, John C. Voss, Atul N. Parikh   +4 more
doaj  

Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes

Lipids in Health and Disease, 2005
Background Transport of fatty acids within the cytosol of adipocytes and their subsequent assimilation into lipid droplets has been thoroughly investigated; however, the mechanism by which fatty acids are transported across the plasma membrane from the ...
Orlando Robert A, Navaratna Deepti, Chanchani Shree, Wilsie Larissa C   +3 more
doaj   +1 more source

Scavenger receptors for oxidized lipoprotein in age-related macular degeneration.

Investigative Ophthalmology and Visual Science, 2007
PURPOSE The accumulation of macrophages is known to be involved in the pathogenesis of age-related macular degeneration (AMD), but the reasons why macrophages accumulate in AMD lesions have not been determined.
M. Kamei, K. Yoneda, N. Kume, Mihoko Suzuki, H. Itabe, K. Matsuda, T. Shimaoka, M. Minami, S. Yonehara, T. Kita, S. Kinoshita   +10 more
semanticscholar   +1 more source

Structural and RNAi characterization of the German cockroach lipophorin receptor, and the evolutionary relationships of lipoprotein receptors

BMC Molecular Biology, 2007
BackgroundLipophorin receptors (LpRs) have been described in a number of insects, but functional studies have been reported only in locusts and mosquitoes.
Laura Ciudad, X. Belles, M. Piulachs
semanticscholar   +1 more source

Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat

Journal of Lipid Research, 1998
Origins of hyperlipidemia and cholestasis that occur during pregnancy were investigated by examining expression of key elements related to plasma and hepatic cholesterol metabolism during pregnancy, lactation, and post-lactation in the rat model.
Jeffery L. Smith, Steven R. Lear, Trudy M. Forte, William Ko, Mara Massimi, Sandra K. Erickson   +5 more
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