Results 31 to 40 of about 2,558,356 (334)

Low Density Lipoprotein Oxidation and Its Pathobiological Significance*

Journal of Biological Chemistry, 1997
Background The fact that low density lipoprotein (LDL) 1 is extremely sus- ceptible to oxidative damage has been known for some time (1, 2), but until quite recently this was primarily a nuisance for the student of lipoprotein metabolism.
D. Steinberg
semanticscholar   +1 more source

A comparative study of the lipid panel levels at different duration time and temperature storage [PDF]

arXiv, 2023
Background: the stability of serum specimen during time storage is importance in clinical and medical science researches in addition of diagnosis. Lipids are organic molecules that classified into 8 classes: fatty acids, phospholipids, glycerolipids, saccharolipids, polyketides, prenol lipids, sterol, and sphingolipids.
arxiv  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Wolbachia Lipoprotein Stimulates Innate and Adaptive Immunity through Toll-like Receptors 2 and 6 to Induce Disease Manifestations of Filariasis

Journal of Biological Chemistry, 2009
Wolbachia endosymbiotic bacteria have been implicated in the inflammatory pathogenesis of filariasis. Inflammation induced by Brugia malayi female worm extract (BMFE) is dependent on Toll-like receptors 2 and 6 (TLR2/6) with only a partial requirement ...
Joseph D. Turner, R. Langley, K. Johnston, K. Gentil, L. Ford, Bo Wu, Maia Graham, F. Sharpley, B. Slatko, E. Pearlman, Mark J. Taylor   +10 more
semanticscholar   +1 more source

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Evolving targets for lipid‐modifying therapy

EMBO Molecular Medicine, 2014
The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low‐density lipoprotein and lipoprotein (a),
Rose Q Do, Stephen J Nicholls, Gregory G Schwartz   +2 more
doaj   +1 more source

Lipoprotein Receptors in Extraembryonic Tissues of the Chicken [PDF]

Journal of Biological Chemistry, 2000
Yolk is the major source of nutrients for the developing chicken embryo, but molecular details of the delivery mechanisms are largely unknown. During oogenesis in the chicken, the main yolk components vitellogenin and very low density lipoprotein (VLDL) are taken up into the oocytes via a member of the low density lipoprotein receptor gene family ...
Wolfgang J. Schneider, Ken A. Lindstedt, Marcela Hermann, Johannes Nimpf, Michelle G. Mahon   +4 more
openaire   +4 more sources

Method for identification of condition-associated public antigen receptor sequences [PDF]

eLife 2018;7:e33050, 2017
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source