Results 51 to 60 of about 2,558,356 (334)

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source

Cerebral autoregulation in patients with acute lacunar infarction: a reliable predictor of outcome

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective To further investigate the association between dynamic cerebral autoregulation (dCA) and the outcomes in patients with acute lacunar infarction. Methods Patients were prospectively and consecutively enrolled at The First Hospital of Jilin University between 2016 and 2023. dCA was monitored at 1–3 and 7–10 days after the stroke.
Xiang‐Kun Si, Song Xue, Xin Zhou, Ya‐Nan Guo, Wen‐Yu Du, Yang Qu, Xin Sun, Zhen‐Ni Guo   +7 more
wiley   +1 more source

Lipolytic remnants of human VLDL produced in vitro: effect of HDL levels in the lipolysis mixtures on the apoCs to apoE ratio and metabolic properties of VLDL core remnants

Journal of Lipid Research, 2000
To determine the role of high-density lipoprotein (HDL) as an acceptor of lipolytic surface remnants of very low density lipoprotein (VLDL) in the metabolism of VLDL core remnants, we examined the effect of HDL levels in the VLDL lipolysis mixture on 1 ...
Byung Hong Chung, Nassrin Dashti
doaj  

Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents

Molecular Imaging, 2008
Low-density lipoprotein (LDL) provides a highly versatile natural nanoplatform for delivery of visible or near-infrared fluorescent optical and magnetic resonance imaging (MRI) contrast agents and photodynamic therapy and chemotherapeutic agents to ...
Jerry D. Glickson, Sissel Lund-Katz, Rong Zhou, Hoon Choi, I-Wei Chen, Hui Li, Ian Corbin, Anatoliy V. Popov, Weiguo Cao, Liping Song, Chenze Qi, Diane Marotta, David S. Nelson, Juan Chen, Britton Chance, Gang Zheng   +15 more
doaj   +1 more source

Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia.

New England Journal of Medicine, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
D. Bilheimer, J. Goldstein, S. Grundy, T. Starzl, Michael S. Brown   +4 more
semanticscholar   +1 more source

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source

Extracellular Matrix Targeted MRI Probes

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Gadolinium based MRI probes targeted to ECM components, either proteins or enzymes, hold promise for accurate molecular characterization and staging of fibrotic diseases in vivo. Non‐covalent binding probes (1), reactive probes (2), and enzyme‐responsive probes (3) are discussed.
Giuseppe Digilio, Sara Lacerda, Begoña Lavin Plaza, Alkystis Phinikaridou   +3 more
wiley   +1 more source

PCSK9 Inhibition: From Current Advances to Evolving Future

Cells, 2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine protease synthesized primarily by the liver. It mainly promotes the degradation of low-density lipoprotein receptor (LDL-R) by binding LDL-R, reducing low-density lipoprotein ...
Chunping Liu, Jing Chen, Huiqi Chen, Tong Zhang, Dongyue He, Qiyuan Luo, Jiaxin Chi, Zebin Hong, Yizhong Liao, Shihui Zhang, Qizhe Wu, Huan Cen, Guangzhong Chen, Jinxin Li, Lei Wang   +14 more
doaj   +1 more source

Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents.

Proceedings of the National Academy of Sciences of the United States of America, 2005
We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normal lipoprotein receptors to other selected cancer-associated ...
G. Zheng, Juan Chen, Hui Li, J. Glickson
semanticscholar   +1 more source

The impact of high density receptor clusters on VEGF signaling [PDF]

EPTCS 125, 2013, pp. 37-52, 2013
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization.
arxiv   +1 more source