Results 61 to 70 of about 783,628 (249)

Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease

Viruses, 2013
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Thomas F. Baumert, Catherine Schuster, Mathieu Lefevre, Mohamed Lamine Hafirassou, Daniel J. Felmlee   +4 more
doaj   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy [PDF]

, 2008
Purpose of the study Fractional clearance rate of apolipoprotein B100-containing lipoproteins is reduced in HIV infection before and after antiretroviral (ARV) treatment [1].
LL Gathercole, M Boothby, S Das, Gathercole, L. L., McGee, K. C. (Kirsty Claire), Tomlinson, Jeremy, Shojaee-Moradie, F, Das, S. (Satyajit), Umpleby, AM, Tomlinson, J. W., Boothby, M., Umpleby, A.M., Shojaee-Moradie, F., F Shojaee-Moradie, JW Tomlinson, K McGee, Boothby, M, M Shahmanesh, Umpleby, A. M., Gathercole, LL, McGee, K, Das, S., Shahmanesh, Mohsen, Tomlinson, JW, Shahmanesh, M, AM Umpleby, Das, S   +26 more
core   +1 more source

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis

Journal of Lipid Research, 2002
During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRα, NR1H3, and LXRβ, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear
Peter A. Edwards, Heidi R. Kast, Andrew M. Anisfeld   +2 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Moorhead, JF, Wheeler, DC, Ruan, XZ, Varghese, Z, Ma, KL, Tao, JL, Powis, SH   +6 more
core  

Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes

Lipids in Health and Disease, 2005
Background Transport of fatty acids within the cytosol of adipocytes and their subsequent assimilation into lipid droplets has been thoroughly investigated; however, the mechanism by which fatty acids are transported across the plasma membrane from the ...
Orlando Robert A, Navaratna Deepti, Chanchani Shree, Wilsie Larissa C   +3 more
doaj   +1 more source

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Mode of Interaction between β2GPI and Lipoprotein Receptors Suggests Mutually Exclusive Binding of β2GPI to the Receptors and Anionic Phospholipids [PDF]

, 2010
SummaryLipoprotein receptors of the LDLR family serve as clearance receptors for β2GPI and as signaling receptors for the β2GPI/antibody complexes in antiphospholipid syndrome.
Lee, Chang-Jin, Beglova, Natalia, De Biasio, Alfredo   +2 more
core   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source