Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells.
Chih-Hsin Lin, JenHer Lu, Hsinyu Lee
doaj +1 more source
Frontiers of antifibrotic therapy in systemic sclerosis [PDF]
Although fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in modern societies, targeted anti-fibrotic therapies are still not approved for most fibrotic disorders. However, intense research over the last decade has
Abraham, DJ +5 more
core
Roles of lipid mediators in early pregnancy events
Background Early pregnancy events, including embryo implantation, are critical for maintaining a healthy pregnancy and facilitating childbirth. Despite numerous signaling pathways implicated in establishing early pregnancy, a comprehensive understanding ...
Shizu Aikawa, Yasushi Hirota
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Potassium channels of the K2P-family control the activity of neuronal cells - TRESK as regulator of inflammatory hyperalgesia [PDF]
Das Empfinden von Schmerz ist für uns überlebenswichtig. Chronischer Schmerz hingegen hat seine physiologische Bedeutung verloren und wird als eigenes Krankheitsbild angesehen. Schmerzempfindung beginnt mit der Nozizeption.
Kollert, Sina
core
LPAR2 Regulates LPA-Induced Osteoclast Sealing Zone Dynamics [PDF]
Bone metastasis is an excruciating consequence of multiple primary cancers, and is commonly treated with bisphosphonate drugs. Osteoclasts, bone-resorbing cells vital to proper bone remodeling and fracture healing, are responsible for the formation of ...
Meyer, Stephanie
core
AGPAT3 Regulates Immune Microenvironment in Osteosarcoma via Lysophosphatidic Acid Metabolism. [PDF]
Su S, Zeng Y, Chen J, Dong X.
europepmc +1 more source
Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality. [PDF]
Li X, Li T, Xuan P, Wang H, Yang J.
europepmc +1 more source
Lysophosphatidic acid receptor 5 (LPAR5; LPA5) [PDF]
openaire +1 more source
Bone Marrow Mononuclear Cells Administration Restore Lysophosphatidic Acid (LPA) Levels and Cellular Signaling Axis in Rats Submitted to Renal Ischemia-Reperfusion. [PDF]
Mattos-Silva P +3 more
europepmc +1 more source
Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma. [PDF]
Kocherlakota S +6 more
europepmc +1 more source

