Results 91 to 100 of about 6,064 (188)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available ...
Abbracchio, MP, Al-Hosaini, K, Aldrich, R, Alexander, SPH, Arumugam, TV, Attali, B, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Bettler, B, Biel, M, Birdsall, NJ, Blaho, V, Boison, D, Bryant, C, Bräuner-osborne, H, Bröer, S, Buneman, OP, Burnstock, G, Bäck, M, Calo, G, Catterall, WA, Ceruti, S, Chan, SL, Chandy, KG, Chazot, P, Chiang, N, Christopoulos, A, Chun, JJ, Chung, JJ, Cidlowski, JA, Clapham, DE, Clapp, L, Connor, MA, Cox, HM, Davenport, AP, Davies, JA, Davies, P, Dawson, PA, Decaen, P, Dent, G, Doherty, P, Douglas, SD, Dubocovich, ML, Fabbro, D, Faccenda, E, Fong, TM, Fowler, CJ, Frantz, A, Fuller, P, Fumagalli, M, Futerman, AH, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Goudet, C, Gregory, K, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hamann, J, Hammond, JR, Hancox, JC, Hanson, J, Hanukoglu, I, Harding, SD, Hay, DL, Hobbs, AJ, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Irving, AJ, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, MF, Jensen, R, Jockers, R, Kaczmarek, LK, Kanai, Y, Karnik, S, Kellenberger, S, Kelly, E, Kemp, S, Kennedy, C, Kerr, ID, Kihara, Y, Kukkonen, J, Larhammar, D, Marrion, NV, Pawson, AJ, Peters, JA, Sharman, JL, Southan, C, Spedding, M, Striessnig, J   +99 more
core  

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]

, 2003
Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik, Heinecke, Karie, Mendel, Jane, Saba, Julie D.   +3 more
core   +1 more source

Course of Pregnancy in a Woman With Familial Chylomicronemia Syndrome Treated With Plozasiran, a Small Interfering RNA Against ApoC3

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Persistent chylomicronemia is associated with severe hypertriglyceridemia (sHTG) and plasma triglycerides (TG) levels sustainably > 10 mmol/L (880 mg/dL) despite lipid lowering therapies. The main risk of persistent chylomicronemia is acute pancreatitis (AP). During the second and third trimester of pregnancy, TG levels significantly increase,
Miriam Larouche, Diane Brisson, Nathalie Roy, Claudy Grenon, Paul Poirier, Ma'an Muhsin, Daniel Gaudet   +6 more
wiley   +1 more source

Arabidopsis phospholipid modifications mediate cellulase‐induced resistance to a fungal peptide antibiotic by imposing cell polarity

New Phytologist, Volume 249, Issue 2, Page 975-991, January 2026.
Summary Plant‐symbiotic Trichoderma fungi attack microorganisms by secreting antibiotic membrane‐permeabilising peptaibols such as alamethicin. These peptaibols also permeabilise plant root epidermis plasma membranes (PMs), but mild pretreatment with Trichoderma cellulase activates a unique cellulase‐induced resistance to alamethicin (CIRA), via an ...
Saritha Panthapulakkal Narayanan, Bradley R. Dotson, Lise Noack, Sanjana Holla, Shichao Ren, Peter Dörmann, Susanne Widell, Staffan Persson, Ida Lager, Allan G. Rasmusson   +9 more
wiley   +1 more source

An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice

Communications Biology
Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as ...
Shuto Tanaka, Masataka Kawakita, Hikaru Yasui, Koichi Sudo, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Hiromitsu Hara, Yoichiro Iwakura, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Taiki Oyama, Himawari Matsunaga, Kazuhiko Takahara   +14 more
doaj   +1 more source

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
A Boucharaba, AD Mackenzie Ross, AJ Houben, AJ Muinonen-Martin, AJ Snider, AL Parrill, AM Algra, Andre Levchenko, Andrew J. Muinonen-Martin, C Carmona-Fontaine, C Scherber, C Zhao, CK Griffith, CM Balch, Colin Lindsay, D Dankort, D Zicha, D Zicha, David A. Knecht, Dorothy C. Bennett, Douwe M. Veltman, E Dona, E Lee, E Sierko, E Theveneau, Elizabeth Smethurst, ET Roussos, F Wach, G Tigyi, G Valentin, G Venkiteswaran, Gabriela Kalna, GL Garcia, J Condeelis, J Condeelis, J Murata, J Sleeman, J Wyckoff, JD Pedelacq, JM Haugh, JP Sleeman, JT Price, K Bandoh, K Jalink, Laura M. Machesky, M Abercrombie, M Gotoh, M Herlyn, M Jongsma, M Zaki, Michael J. O. Wakelam, MJ Payette, N Aaltonen, Olivia Susanto, Owen J. Sansom, P Berens, P Timpson, PN Devreotes, Qifeng Zhang, RA Sturm, Robert H. Insall, Robert Herd, Robert Jones, RR Langley, S Kuriyama, S Toetsch, S Toyozawa, SA Jordan, SH Zigmond, SH Zigmond, SK Hughes-Alford, W Wang, William J. Faller   +72 more
core   +3 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, Volume 599, Issue 24, Page 3569-3590, December 2025.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway [PDF]

, 2019
The phospholipid l-α-lysophosphatidylinositol (LPI), an endogenous ligand for GPR55, is elevated in patients with acute coronary syndrome, and a GPR55 antagonist cannabidiol (CBD) reduces experimental ischemia/reperfusion (I/R) injury.
Jönsson-Rylander, Ann Cathrine, Lipina, Christopher, Robertson-Gray, Olivia J., Ryberg, Erik, Wainwright, Cherry L., Walsh, Sarah K.   +5 more
core   +3 more sources

Mfsd2a‐Targeted Therapy for Ischemic Stroke: Mechanisms, Evidence, and Future Prospects

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This graphical abstract illustrates the central role of Mfsd2a in maintaining blood–brain barrier (BBB) integrity under physiological conditions and its dysregulation following ischemic stroke. In the normal brain (left), Mfsd2a is highly expressed on brain microvascular endothelial cells (BMECs), where it inhibits caveolae‐mediated transcytosis and ...
Zhidong He, Jing Sun
wiley   +1 more source

Manipulation of lipid rafts in neuronal cells [PDF]

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core   +1 more source