Results 81 to 90 of about 3,169 (190)

The effect of membrane active agents on human leukaemia cells [PDF]

, 1998
This Thesis investigates the effect of membrane-active agents, such as synthetic ether lipids (SEL), local anaesthetics and polyunsaturated fatty acids (PUFAs) on human leukaemia cells.
Jones, Eirian Wynne
core  

G Protein–Coupled Receptors as Potential Drug Targets for Lymphangiogenesis and Lymphatic Vascular Diseases

, 2009
G-protein coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety of human diseases.
William P. Dunworth, Caron, K. M., Kathleen M. Caron, Dunworth, W. P.   +3 more
core   +1 more source

Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C

, 1994
Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.
Grünbaum, L., Hummel, R., Schächtele, C., Wenzel-Seifert, K., Seifert, Roland   +4 more
core   +1 more source

Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice

, 2016
Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as a potent activator for various types of immune cells ...
Schaftenaar, F.H., Kuiper, J., Swart, M., Santbrink, P.J. van, Kroner, M.J., Puijvelde, G.H.M. van, Heijden, T. van der, Bot, I., Kritikou, E.   +8 more
core   +1 more source

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12 [PDF]

, 2018
GPR3, GPR6, and GPR12 are three orphan receptors that belong to the Class A family of G-protein-coupled receptors (GPCRs). These GPCRs share over 60% of sequence similarity among them.
Reggio, Patricia H., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Towards selective lysophospholipid GPCR modulators

, 2014
G-protein-coupled receptors (GPCRs) that recognize the lysophospholipids (LPLs) are grouped into two phylogenetically distinct families: the endothelial differentiation gene (Edg) and non-Edg GPCRs. Owing to their more recent identification, and hindered
Sweet, Matthew J, Archbold, Julia K, Martin, Jennifer L, Martin, Jennifer L., Sweet, Matthew J., Archbold, Julia K.   +5 more
core   +1 more source

Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate

, 2000
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (Sph-1-P) are known as structurally related bio-active lipids activating platelets through their respective receptors.
Satomi Shibata, Yukio Ozaki, Yatomi, Yutaka, Yutaka Yatomi, Igarashi, Yasuyuki, Ken Motohashi, Motohashi, Ken, Yasuyuki Igarashi, Shibata, Satomi, Ozaki, Yukio   +9 more
core   +1 more source

A Single Amino Acid Determines Lysophospholipid Specificity of the S1P 1 (EDG1) and LPA1 (EDG2) Phospholipid Growth Factor Receptors

, 2001
The phospholipid growth factors sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are ligands for the related G protein-coupled receptors S1P1/EDG1 and LPA1/EDG2, respectively.
Parrill, Abby L., Bautista, Debra L., Wang, De An, Lorincz, Zsolt, Liliom, Karoly, Tigyi, Gabor   +5 more
core   +1 more source

Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells

, 2005
Human embryonic stem cells (hESCs) have great potential for use in research and regenerative medicine, but very little is known about the factors that maintain these cells in the pluripotent state. We investigated the role of three major mitogenic agents
Pitson, S., Filipczyk, A., Pera, Martin F., Koh, Karen L. L., Pitson, Stuart M., Pebay, Alice, Peh, Gary S.-L., Nguyen, Linh T.V., Wong, R., Tellis, Irene, Koh, K., Peh, G., Pebay, A., Wong, Raymond C. B., Tellis, I., Wolvetang, E., Nguyen, L., Pera, M., Wolvetang, Ernst J., Fykilipcz, Adam   +19 more
core   +1 more source

Pharmacological blockade of G-protein coupled receptors : interventions to alter expression or internalization [PDF]

, 2004
Hangartner, Christoph
core   +1 more source