Results 61 to 70 of about 2,946 (161)

An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice

Communications Biology
Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as ...
Shuto Tanaka, Masataka Kawakita, Hikaru Yasui, Koichi Sudo, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Hiromitsu Hara, Yoichiro Iwakura, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Taiki Oyama, Himawari Matsunaga, Kazuhiko Takahara   +14 more
doaj   +1 more source

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at‐risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID‐19 severity and progression.
Melissa Goris, Merys Valdez, Lieke Lamont, Wei Yang, Amy Harms, Naama Karu, Sabine Bos, Jelte Geerlings, Tom Ottenhoff, Roula Tsonaka, Anna HE Roukens, M. Sesmu Arbous, Simone A. Joosten, Thomas Hankemeier, Alida Kindt, In collaboration with BEAT‐COVID group, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei   +57 more
wiley   +1 more source

Reprogramming lipid metabolism for cognitive restoration in Alzheimer's via PLA2G4E

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Growing evidence implicates dysregulated brain lipid metabolism in Alzheimer's disease (AD) pathogenesis, influencing membrane integrity, neuroinflammation, and amyloid beta and tau pathology, thereby representing a promising therapeutic target.
Sara Badesso, María Espelosín, Cristina Alonso, Alejandro Montilla, Maria Collantes, Mar Cuadrado‐Tejedor, Ana García‐Osta   +6 more
wiley   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Lysophosphatidic acid (LPA)/LPA1 axis induces goblet cell hyperplasia via activation of pulmonary neuroendocrine cells in a chronic mouse model of asthma

Allergology International
Background: Lysophosphatidic acid (LPA) and its receptor LPA1 have been implicated in tissue inflammation and fibrosis; however, their role in mucus overproduction remains unclear.
Shotaro Tachibana, Hirohisa Ogawa, Mayuko Ichimura-Shimizu, Takahiro Takayama, Hiroki Bando, Seidai Sato, Koichi Inoue, Makoto Kurano, Yasuhiko Nishioka, Koichi Tsuneyama   +9 more
doaj   +1 more source

Lysophospholipid (S1P) receptors in GtoPdb v.2025.3

IUPHAR/BPS Guide to Pharmacology CITE
Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid receptors [98]) are activated by the endogenous lipid sphingosine 1-phosphate (S1P). Originally cloned as orphan members of the endothelial differentiation gene (edg) family [16, 125], the receptors are currently designated as S1P1R ...
Victoria Blaho, Jerold Chun, Deron R. Herr, Danielle Jones, Yasuyuki Kihara   +4 more
openaire   +1 more source

Zexie decoction alleviates hyperlipidemia through modulation of the PPAR signaling pathway and lysophospholipid metabolism. [PDF]

Pharm Biol
Li S, Wen ZQ, Yan P.
europepmc   +1 more source

Lysophosphatidylethanolamine (LysoPE) in health and disease: a narrative review of its pathophysiological mechanisms and translational potential as a biomarker. [PDF]

Front Cell Dev Biol
Wang KM, Shang XY, Shi XG.
europepmc   +1 more source

Alveolar Lipid-Macrophage Networks at the Intersection of Pulmonary Fibrosis. [PDF]

Cells
Apte SH, Lutzky VP, Groves PL, Chambers DC.   +3 more
europepmc   +1 more source

Lysophosphatidylcholine homeostasis via the Lands cycle regulates root growth in Arabidopsis. [PDF]

Plant Cell Physiol
Wang L, Kazachkov M, Qin L, Niu Y, Wei Y, Li Q, Zou J.   +6 more
europepmc   +1 more source