Results 51 to 60 of about 3,169 (190)

Hepatic uptake of chylomicron remnants

Journal of Lipid Research, 1997
Chylomicrons are formed in the intestine and transport dietary triglyceride to peripheral tissues and cholesterol to the liver. The enzyme lipoprotein lipase, with apolipoprotein (apo)C-II as a co-factor, hydrolyzes chylomicron triglyceride allowing the ...
A D Cooper
doaj   +1 more source

Systems‐Level Plant Responses Reveal Pseudomonas‐Mediated Growth Promotion in Brachypodium Under Nitrogen Limitation

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant growth–promoting bacteria can enhance plant performance under nutrient limitation, yet the underlying plant molecular responses remain incompletely resolved. We investigated growth promotion by Pseudomonas koreensis in Brachypodium distachyon under contrasting nitrogen (N) regimes using time‐resolved phenotyping, elemental analysis ...
Stefan Sanow, Melissa Mantz, Holger Wissel, Atul Bhatnagar, Elena Sturm, Jana M. Kelm, Robert Walker, Andreas Lücke, Gabriel Schaaf, Pitter F. Huesgen, Ute Roessner, Michelle Watt, Borjana Arsova   +12 more
wiley   +1 more source

Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis

Pharmaceuticals, 2012
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, is generated from sphingosine by sphingosine kinases and binds five known cell surface receptors.
Kunitomo Adachi, Kenji Chiba
doaj   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid[S]

Journal of Lipid Research, 2013
We previously reported that lysophosphatidic acid (LPA) inhibits the neuronal differentiation of human embryonic stem cells (hESC). We extended these studies by analyzing LPA舗s effects on the expansion of neural stem/progenitor cells (NS/PC) derived from
Frisca Frisca, Duncan E. Crombie, Mirella Dottori, Yona Goldshmit, Alice Pébay   +4 more
doaj   +1 more source

Lysophospholipid Receptor-Mediated Calcium Signaling in Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2008
The lysophospholipids, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), stimulate chemotaxis and induce differentiation of human keratinocytes. As Ca(2+) plays an important role in keratinocyte differentiation, we studied Ca(2+) signaling by S1P and LPA in these cells, known to express mRNA transcripts of the S1P(1-5) and LPA(1-3 ...
Lichte, Karin, Rossi, Roberto, Danneberg, Kerstin, Braak, Michael ter, Kürschner, Ulrich, Jakobs, Karl H., Kleuser, Burkhard, Heringdorf, Dagmar Meyer zu   +7 more
openaire   +2 more sources

Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5810-5826, July 2026.
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang, Borja Martinez‐Tellez, Alida Kindt, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Jonatan R. Ruiz, Lucas Jurado‐Fasoli   +7 more
wiley   +1 more source

Lysophospholipid (S1P) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

, 2019
Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid receptors [70]) are activated by the endogenous lipid sphingosine 1-phosphate (S1P). Originally cloned as orphan members of the endothelial
Mpamhanga, Chido, Mizuno, Hirotaka, Blaho, Victoria, Jonnalagadda, Deepa, Chun, Jerold, Kihara, Yasuyuki, Spiegel, Sarah, Tan, Valerie   +7 more
core   +1 more source

Exploring SK/S1P/S1PR pathway as a target for antiviral drug development

Health Sciences Review
Lysophospholipids are a class of simple phospholipids that shows their biological effects through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is one of the most studied lysophospholipid having wide role in various ...
Sharada Prasanna Swain, Chandra Sekhara Mahanta, Madan Maurya, Debabrata Mandal, Vipan Parihar, V. Ravichandiran   +5 more
doaj   +1 more source

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations.

PLoS Computational Biology, 2013
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator which activates G protein-coupled sphingosine 1-phosphate receptors and thus evokes a variety of cell and tissue responses including lymphocyte trafficking, endothelial development, integrity ...
Shuguang Yuan, Rongliang Wu, Dorota Latek, Bartosz Trzaskowski, Slawomir Filipek   +4 more
doaj   +1 more source