Results 161 to 170 of about 6,064 (188)

Leukemia-expanded splenic CD81+ erythroblasts potentiate disease progression in mice by reshaping leukemic cell metabolism. [PDF]

J Clin Invest
Li Y, Cao J, Tong J, Tang P, Chen H, Sun G, Yang Z, Zhang X, Dong F, Yang S, Gao J, Zhao X, Ma J, Wang D, Zhang L, Wang L, Cheng T, Cheng H, Shi L.   +18 more
europepmc   +1 more source

Regulation of osmolyte efflux by lysophospholipid receptors

, 2016
Heacock, A, Dodd, M, Fisher, S
openaire   +1 more source

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Lysophospholipid Receptors

Annual Review of Pharmacology and Toxicology, 2001
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate, produce many cellular effects. However, the prolonged absence of any cloned and identified LP receptor has left open the question of how these lipids actually bring about these effects.
N, Fukushima, I, Ishii, J J, Contos, J A, Weiner, J, Chun   +4 more
openaire   +3 more sources

Lysophospholipids--Receptor Revelations

Science, 2001
Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in ...
T, Hla, M J, Lee, N, Ancellin, J H, Paik, M J, Kluk   +4 more
openaire   +2 more sources

Lysophospholipid Receptors: Signaling and Biology

Annual Review of Biochemistry, 2004
▪ Abstract  Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii, Nobuyuki, Fukushima, Xiaoqin, Ye, Jerold, Chun   +3 more
openaire   +2 more sources

Lysophospholipid receptors in cell signaling

Biochemistry (Moscow), 2007
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors.
T I, Torkhovskaya, O M, Ipatova, T S, Zakharova, M M, Kochetova, E M, Khalilov   +4 more
openaire   +2 more sources

Cell surface receptors in lysophospholipid signaling

Seminars in Cell & Developmental Biology, 2004
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival ...
Brigitte, Anliker, Jerold, Chun
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Roles for lysophospholipid S1P receptors in multiple sclerosis

Critical Reviews in Biochemistry and Molecular Biology, 2010
Sphingosine 1-phosphate (S1P) signaling in the treatment of multiple sclerosis (MS) has been highlighted by the efficacy of FTY720 (fingolimod), which upon phosphorylation can modulate S1P receptor activities. FTY720 has become the first oral treatment for relapsing MS that was approved by the FDA in September 2010. Phosphorylated FTY720 modulates four
Kyoko, Noguchi, Jerold, Chun
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Microglial activation state and lysophospholipid acid receptor expression

International Journal of Developmental Neuroscience, 2003
AbstractWe used a simple commercial magnetic immunobead method for the preparation of acutely isolated microglial cells from postnatal days 1–3 rat brain. With the exception of a 15 min enzyme incubation, all stages are carried out at 4 °C, minimizing the opportunity for changes in gene expression during the isolation to be reflected in changes in ...
Chui-Se, Tham, Fen-Fen, Lin, Tadimeti S, Rao, Naichen, Yu, Michael, Webb   +4 more
openaire   +2 more sources