Results 161 to 170 of about 3,169 (190)

Neurobiology of Receptor‐Mediated Lysophospholipid Signaling: From the First Lysophospholipid Receptor to Roles in Nervous System Function and Development

Annals of the New York Academy of Sciences, 2000
Abstract: Identification of the first lysophospholipid receptor, LPA1/Vzg‐1, cloned by way of neurobiological analyses on the embryonic cerebral cortex, has led to the realization and demonstration that there exist multiple, homologous LP receptors, including those encoded by a number of orphan receptor genes known as “Edg,” all of which are members ...
J, Chun, J A, Weiner, N, Fukushima, J J, Contos, G, Zhang, Y, Kimura, A, Dubin, I, Ishii, J H, Hecht, C, Akita, D, Kaushal   +10 more
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Lysophospholipid Receptors: Implications for Neural Signaling

Critical Reviews in Neurobiology, 1999
Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) represent quantitatively minor phospholipid species that nonetheless are capable of acting as extracellular signals. As an organ system dominated by lipids, the nervous system would seem a likely benefactor of this form of intercellular signaling.
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Microglial activation state and lysophospholipid acid receptor expression

International Journal of Developmental Neuroscience, 2003
AbstractWe used a simple commercial magnetic immunobead method for the preparation of acutely isolated microglial cells from postnatal days 1–3 rat brain. With the exception of a 15 min enzyme incubation, all stages are carried out at 4 °C, minimizing the opportunity for changes in gene expression during the isolation to be reflected in changes in ...
Chui-Se, Tham, Fen-Fen, Lin, Tadimeti S, Rao, Naichen, Yu, Michael, Webb   +4 more
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Long-lasting enhancement of ACh receptor currents by lysophospholipids

Molecular Brain Research, 1997
Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation.
Y, Ikeuchi, T, Nishizaki, T, Matsuoka, K, Sumikawa   +3 more
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Lysophospholipid receptor‐dependent and ‐independent calcium signaling

Journal of Cellular Biochemistry, 2004
AbstractChanges in cellular Ca2+ concentrations form a ubiquitous signal regulating numerous processes such as fertilization, differentiation, proliferation, contraction, and secretion. The Ca2+ signal, highly organized in space and time, is generated by the cellular Ca2+ signaling toolkit.
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Lysophospholipid Activation of G Protein-Coupled Receptors

2008
One of the major lipid biology discoveries in last decade was the broad range of physiological activities of lysophospholipids that have been attributed to the actions of lysophospholipid receptors. The most well characterized lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Documented cellular effects of these lipid
Tetsuji, Mutoh, Jerold, Chun
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Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Among the family of lipid-derived mediators, the group of lysophospholipids including lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have growth-related and -unrelated effects on diverse cell types including lymphocytes, macrophages, smooth muscle cells, endothelial cells, and neuronal cells.
Markus H, Gräler, Edward J, Goetzl
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Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

Experimental Cell Research, 1999
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated ...
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Lysophospholipid Mediators: Their Receptors and Synthetic Pathways

2015
It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G protein-coupled receptors (GPCRs). Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo.
Kuniyuki Kano, Kumiko Makide, Jun Ishiguro, Hiroshi Yukiura, Shizu Aikawa, Akiharu Uwamizu, Yuji Shinjo, Kahori Namiki, Hiroki Kawana, Saki Nemoto, Hirotaka Matsumoto, Ryoji Kise, Asuka Inoue, Junken Aoki   +13 more
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Role of Lysophospholipid Metabolism in Chronic Myelogenous Leukemia Stem Cells

Cancers, 2021
Kazuhito Naka, Naka Kazuhito
exaly