Results 171 to 180 of about 6,064 (188)

Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2004
Some of the biological effects of lipoproteins have been attributed to their association with lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC). These lysophospholipids mediate multiple biological responses via several G protein-coupled receptors (GPR).
Chinh Quoc, Duong, Salim Maa, Bared, Ahmad, Abu-Khader, Christa, Buechler, Anna, Schmitz, Gerd, Schmitz   +5 more
openaire   +3 more sources

Lysophospholipid Receptors: Implications for Neural Signaling

Critical Reviews in Neurobiology, 1999
Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) represent quantitatively minor phospholipid species that nonetheless are capable of acting as extracellular signals. As an organ system dominated by lipids, the nervous system would seem a likely benefactor of this form of intercellular signaling.
openaire   +2 more sources

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

Pharmacological Reviews, 2002
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules. These lipid mediators are pleiotropic; among the most common cellular responses are mitogenesis, cell survival (anti-apoptosis), inhibition of adenylyl cyclase and calcium mobilization.
Chun, Jerold, Goetzl, Edward J, Hla, Timothy, Igarashi, Yasuyuki, Lynch, Kevin R, Moolenaar, Wouter, Pyne, Susan, Tigyi, Gabor   +7 more
openaire   +2 more sources

Chemical approaches to the lysophospholipid receptors

Prostaglandins & Other Lipid Mediators, 2005
Both ligand-based and GPCR privileged scaffold chemical tools have recently emerged to provide new insights into the function and physiology of the GPCR lysophospholipid receptors both in vitro and in vivo. Both rational, design-based approaches as well as hybrid approaches where high throughput screening has been coupled to an understanding of ...
openaire   +2 more sources

Lysophospholipid Activation of G Protein-Coupled Receptors

2008
One of the major lipid biology discoveries in last decade was the broad range of physiological activities of lysophospholipids that have been attributed to the actions of lysophospholipid receptors. The most well characterized lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Documented cellular effects of these lipid
Tetsuji, Mutoh, Jerold, Chun
openaire   +2 more sources

Neurobiology of Receptor‐Mediated Lysophospholipid Signaling: From the First Lysophospholipid Receptor to Roles in Nervous System Function and Development

Annals of the New York Academy of Sciences, 2000
Abstract: Identification of the first lysophospholipid receptor, LPA1/Vzg‐1, cloned by way of neurobiological analyses on the embryonic cerebral cortex, has led to the realization and demonstration that there exist multiple, homologous LP receptors, including those encoded by a number of orphan receptor genes known as “Edg,” all of which are members ...
J, Chun, J A, Weiner, N, Fukushima, J J, Contos, G, Zhang, Y, Kimura, A, Dubin, I, Ishii, J H, Hecht, C, Akita, D, Kaushal   +10 more
openaire   +2 more sources

Lysophospholipid receptor‐dependent and ‐independent calcium signaling

Journal of Cellular Biochemistry, 2004
AbstractChanges in cellular Ca2+ concentrations form a ubiquitous signal regulating numerous processes such as fertilization, differentiation, proliferation, contraction, and secretion. The Ca2+ signal, highly organized in space and time, is generated by the cellular Ca2+ signaling toolkit.
openaire   +2 more sources

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

Experimental Cell Research, 1999
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated ...
openaire   +2 more sources

Long-lasting enhancement of ACh receptor currents by lysophospholipids

Molecular Brain Research, 1997
Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation.
Y, Ikeuchi, T, Nishizaki, T, Matsuoka, K, Sumikawa   +3 more
openaire   +2 more sources

Lysophospholipid Mediators: Their Receptors and Synthetic Pathways

2015
It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G protein-coupled receptors (GPCRs). Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo.
Kuniyuki Kano, Kumiko Makide, Jun Ishiguro, Hiroshi Yukiura, Shizu Aikawa, Akiharu Uwamizu, Yuji Shinjo, Kahori Namiki, Hiroki Kawana, Saki Nemoto, Hirotaka Matsumoto, Ryoji Kise, Asuka Inoue, Junken Aoki   +13 more
openaire   +1 more source