Results 81 to 90 of about 6,064 (188)

Lysophospholipids and their receptors in the central nervous system [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied lysophospholipids, are known to influence diverse biological events, including organismal development as well as function and pathogenesis within multiple organ systems.
Ji Woong, Choi, Jerold, Chun
openaire   +2 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

The evolution and comparative neurobiology of endocannabinoid signalling [PDF]

, 2012
CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A., Maurice R. Elphick, Montell C., Soderstrom K., Soderstrom K.   +4 more
core   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

The Effect of Different Lysophospholipid Levels on Blood and Milk Biochemical Parameters, Liver and Rumen Enzymes, and Rumen Microbial Population in Early Lactation of Holstein Dairy Cows [PDF]

پژوهشهای تولیدات دامی
Extended Abstract Background: High-yielding cows, especially at the beginning of the lactation period, are mainly in a negative energy balance. This problem occurs due to energy consumption less than the requirements for high production, which causes the
Matin Movagharnezhad, Yadollah Chashnidel, Asadollah Teymouri Yansari, Mohsen Gholizadeh   +3 more
doaj  

Lysolipid containing liposomes for transendothelial drug delivery [PDF]

, 2012
BACKGROUND: Designing efficient 'vectors', to deliver therapeutics across endothelial barriers, in a controlled manner, remains one of the key goals of drug development. Recently, transcytosis of liposome encapsulated fluorescence marker calcein across a
Janez trancar, Tilen Koklic
core   +1 more source

Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic red blood cell (RBC) transfusion sustains patients with diverse hematologic disorders, but repeated transfusion leads to iron overload and alloimmunization. Reducing transfusion burden requires identifying donor units that circulate more effectively after storage, yet determinants of this variability remain incompletely defined.
James C. Zimring, Ariel M. Hay, Monika Dzieciatkowska, Daniel Stephenson, Zachary B. Haiman, Steven Kleinman, Philip J. Norris, Michael P. Busch, Nareg Roubinian, Elisa Fermo, Paola Bianchi, Gregory R. Keele, Grier P. Page, Angelo D'Alessandro   +13 more
wiley   +1 more source

Endocannabinoid system and anticancer properties of cannabinoids [PDF]

, 2016
Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nowak, Agnieszka, Słomski, Ryszard, Zeyland, Joanna, Śledziński, Paweł   +3 more
core   +1 more source

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3 [PDF]

Journal of Clinical Investigation, 2004
HDL is a major atheroprotective factor, but the mechanisms underlying this effect are still obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although the responsible HDL entities and signaling pathways have remained enigmatic.
Nofer, Jerzy-Roch, van der Giet, Markus, Tölle, Markus, Wolinska, Iza, von Wnuck Lipinski, Karin, Baba, Hideo Andreas, Tietge, Uwe J, Gödecke, Axel, Ishii, Isao, Kleuser, Burkhard, Schäfers, Michael, Fobker, Manfred, Zidek, Walter, Assmann, Gerd, Chun, Jerold, Levkau, Bodo   +15 more
openaire   +3 more sources

Blocking Sphingosine 1‐phosphate Metabolism With Fingolimod Prevents the Progression of Vascular Smooth Muscle Cells Calcification in Chronic Kidney Disease

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
ABSTRACT Patients with chronic kidney disease, and particularly those under hemodialysis, are prone to develop cardiovascular complications, mostly due to the exacerbation of vascular calcification. Vascular calcification relies on the transdifferentiation of vascular smooth muscle cells into calcifying cells.
Najwa Skafi, Solenne Pelletier, Christophe O. Soulage, Sarah Nahle, Beatriz O. Da Cruz, Rayan Othmani, Anne Briolay, Sophie Reibel, Nicolas Vitale, Eva Hamade, Bassan Badran, David Magne, Rene Buchet, Milena B. Stockler‐Pinto, Denis Fouque, Saida Mebarek, Leyre Brizuela   +16 more
wiley   +1 more source