Results 111 to 120 of about 40,887 (228)

Effect of NDP-a-MSH on PPAR-c and –b Expression and Anti-Inflammatory Cytokine Release in Rat Astrocytes and Microglia [PDF]

, 2013
Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. a-melanocytestimulating hormone (
Carniglia, Lila, Caruso, Carla Mariana, Durand, Daniela Elizabeth, Lasaga, Mercedes Isabel   +3 more
core   +1 more source

Global consensus on the management of melanin hyperpigmentation disorders

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 760-772, May 2026.
A global Delphi consensus of 10 dermatology experts established evidence‐based recommendations for melanin hyperpigmentation disorders, providing unified classification, photoprotection guidance and treatment algorithms. This framework harmonizes terminology and supports individualized management across diverse skin types and health systems.
Thierry Passeron, Seemal R. Desai, Marwa Abdallah, Firas Al‐Niaimi, Ncoza Dlova, Pearl E. Grimes, Jorge Ocampo‐Candiani, Rashmi Sarkar, Leihong Flora Xiang, Helio Amante Miot   +9 more
wiley   +1 more source

Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum

Frontiers in Neuroanatomy, 2014
The striatum harbors two neuronal populations that enable action selection. One population represents the striatonigral pathway, expresses the dopamine receptor D1 (DRD1) and promotes the execution of motor programs, while the other population represents
Ralph J Oude-Ophuis, Ralph J Oude-Ophuis, Arjen J Boender, Rea evan Rozen, Roger A Adan   +4 more
doaj   +1 more source

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy [PDF]

, 2016
We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice.
D'Amico, M., D'Amico, M., Di Filippo, C., Di Filippo, C., Ferraraccio, F., Ferraraccio, F., Gesualdo, C., Gesualdo, C., Getting, S.J., Getting, S.J., Grieco, P., Grieco, P., Kaneva, M.K., Kaneva, M.K., Maisto, R., Maisto, R., Merlino, F., Merlino, F., Perretti, M., Perretti, M., Rossi, S., Rossi, S., Simonelli, F., Simonelli, F., Surace, E., Surace, E., Testa, F., Testa, F., Trotta, M.C., Trotta, M.C.   +29 more
core   +4 more sources

The role of insulin receptor substrate 2 in hypothalamic and beta cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H, Ashford, MLJ, Barsh, GS, Batterham, RL, Bedford, DC, Bell, JD, Choudhury, AI, Claret, M, Clements, M, Diakonov, I, Heffron, H, Hisadome, K, MacColl, G, Moosajee, V, Selman, C, Simmgen, M, Smith, MA, Speakman, JR, Withers, DJ, Xu, AW   +19 more
core  

5-HT obesity medication efficacy via POMC activation is maintained during aging [PDF]

, 2014
Peer reviewedPublisher ...
Billups, Brian, Burdakov, Denis, Burke, Luke K, D'Agostino, Giuseppe, Doslikova, Barbora, Evans, Mark L, Farooq, Gala, Garfield, Alastair S, Heisler, Lora, Low, Malcolm, Rubinstein, Marcelo   +10 more
core   +3 more sources

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4437-4441, June 2026.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
doaj   +1 more source

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity

Biomolecules
Genetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj   +1 more source

Annexin 1 and Melanocortin Peptide Therapy for Protection Against Ischaemic-Reperfusion Damage in the Heart

The Scientific World Journal, 2006
Cardiovascular disease is a major cause of mortality within the western world affecting 2.7 million British people. This review highlights the beneficial effects of naturally occurring hormones and their peptides, in myocardial ischaemic-injury (MI ...
F.N.E. Gavins, G. Leoni, S.J. Getting
doaj   +1 more source