Results 41 to 50 of about 30,864 (195)

Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes

BMC Evolutionary Biology, 2007
Background The melanocortin (MC) receptors have a key role in regulating body weight and pigmentation. They belong to the rhodopsin family of G protein-coupled receptors (GPCRs).
Kawauchi Hiroshi, Enberg Johan, Ringholm Aneta, Löwgren Maja, Takahashi Akiyoshi, Klovins Janis, Haitina Tatjana, Larson Earl T, Fredriksson Robert, Schiöth Helgi B   +9 more
doaj   +1 more source

Activation of Melanocortin Receptors as a Potential Strategy to Reduce Local and Systemic Reactions Induced by Respiratory Viruses

Frontiers in Endocrinology, 2020
The clinical hallmarks of infections caused by critical respiratory viruses consist of pneumonia, which can progress to acute lung injury (ALI), and systemic manifestations including hypercoagulopathy, vascular dysfunction, and endotheliitis. The disease
Caterina Lonati, Stefano Gatti, Anna Catania   +2 more
doaj   +1 more source

The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials

Cells, 2023
The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory ...
Antonietta Gerarda Gravina, Raffaele Pellegrino, Tommaso Durante, Giovanna Palladino, Giuseppe Imperio, Giovanbattista D’Amico, Maria Consiglia Trotta, Marcello Dallio, Mario Romeo, Michele D’Amico, Alessandro Federico   +10 more
doaj   +1 more source

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer

Frontiers in Endocrinology, 2021
The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Meng Wang, Linyu Pi, Xiaowei Lei, Lei Li, Jing Xu, Zhe Kuang, Cong Zhang, Liang Li, Chao Zhang   +8 more
doaj   +1 more source

Health‐Related Quality of Life, Everyday Executive Functioning, and Eating Behavior in Adults With Bardet–Biedl Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Bardet–Biedl syndrome (BBS) is a rare genetic condition with a broad phenotypic spectrum. Knowledge about quality of life, executive functioning, and eating behavior in adults with BBS remains limited. This study aimed to assess health‐related quality of life (HRQoL), everyday executive functioning, and eating behavior in adults with BBS and ...
Cecilie Fremstad Rustad, Charlotte von der Lippe, Hilde Nordgarden, Jeanette Ullmann Miller, Mina Susanne Weedon‐Fekjær, Ragnheidur Bragadottir, Solrun Sigurdardottir   +6 more
wiley   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player

Pharmaceuticals, 2021
The melanocortin system encompasses melanocortin peptides, five receptors, and two endogenous antagonists. Besides pigmentary effects generated by α-Melanocytic Hormone (α-MSH), new physiologic roles in sexual activity, exocrine secretion, energy ...
Roshan Dinparastisaleh, Mehdi Mirsaeidi
doaj   +1 more source

Melanocortin receptors in leptin effects [PDF]

Nature, 1997
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J., Yagaloff, Keith A., Fisher, Stewart L., Burn, Paul, Thiele, Todd E., Dijk, Gertjan van, Baskin, Denis G., Schwartz, Michael W.   +7 more
openaire   +3 more sources

The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]

PLoS ONE, 2010
BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser, Thomas Brzoska, Vinzenz Oji, Matteo Auriemma, Maik Voskort, Verena Kupas, Lars Klenner, Cornelius Mensing, Axel Hauschild, Stefan Beissert, Thomas A Luger   +10 more
doaj   +1 more source

Differential effects of melanocortin peptides on neural melanocortin receptors.

Molecular Pharmacology, 1994
Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H., Adan, R.A.H., Cone, R.D., Burbach, J.P.H.   +3 more
openaire   +4 more sources