Results 21 to 30 of about 32,241 (233)

Structure, function and regulation of the melanocortin receptors [PDF]

European Journal of Pharmacology, 2011
Melanocortin receptors belong to the seven-transmembrane (TM) domain proteins that are coupled to G-proteins and signaled through intracellular cyclic adenosine monophosphate. Many structural features conserved in other G-protein coupled receptors (GPCRs) are found in the melanocortin receptors. There are five melanocortin receptor subtypes and each of
openaire   +4 more sources

Loss-of-function mutations in the melanocortin-2-receptor (mc2r) lead to skin hyperpigmentation in teleost fish [PDF]

Scientific Reports
Melanocortins regulate pigmentation via melanocortin receptors (MCRs), which are highly conserved across vertebrates. Unlike other MCRs, the melanocortin 2 receptor (MC2R) is exclusively activated by ACTH; however, its role in pigmentation remains ...
Elisa Barreiro-Docío, Laura Guerrero-Peña, Priyanka Soni, Luis Méndez-Martínez, Carolina Costas-Prado, Maria Victoria Alvarado, José Antonio Vázquez, Lluís Tort, José Miguel Cerdá-Reverter, Josep Rotllant   +9 more
doaj   +2 more sources

“Are melanocortin receptors constitutively active in vivo?” [PDF]

European Journal of Pharmacology, 2013
Constitutive activity is defined as ligand-independent activity, resulting in the production of a second messenger, even in the absence of an agonist. There has been widespread acceptance of the concept of G-protein-coupled receptor constitutive activity, with this activity specifically blocked by inverse agonists, a particular class of ligands often ...
Coll, Anthony P.
openaire   +3 more sources

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain

Frontiers in Molecular Neuroscience, 2023
Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in regulating a variety of functions across many species. For example, the dysregulation of these receptors results in obesity and dysfunction in sexual behaviors.
Megan A. L. Hall, Abigail L. Kohut-Jackson, Anna C. Peyla, Gloria D. Friedman, Nicole J. Simco, Johnathan M. Borland, Robert L. Meisel   +6 more
doaj   +1 more source

Identification of novel GPCR partners of the central melanocortin signaling

Molecular Metabolism, 2021
Objective: Homo- or heterodimerization of G protein–coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo.
Yunpeng Li, Xiaozhu Wang, Liumei Lu, Meng Wang, Yue Zhai, Xiaolu Tai, Diliqingna Dilimulati, Xiaowei Lei, Jing Xu, Cong Zhang, Yanbin Fu, Shen Qu, Qingfeng Li, Chao Zhang   +13 more
doaj   +1 more source

Melanocortin receptors in GtoPdb v.2021.3 [PDF]

, 2021
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH ...
Gantz, Ira, Chai, Biao-Xin, Haskell-Luevano, Carrie, Wikberg, Jarl E. S., Tatro, Jeffrey B., Clark, Adrian J. L., Schiöth, Helgi, Pouton, Colin, Caruso, Vanni, Mountjoy, Kathleen G., Fong, Tung M., Eberle, Alex N., Cone, Roger D., Farooqi, Sadaf, Hruby, Victor J.   +14 more
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Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]

, 2007
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Stäubert, Claudia, Tarnow, Patrick, Pitra, Christian, Gudermann, T., Stäubert, C. ; https://orcid.org/, Tarnow, P., Brumm, H., Römpler, Holger, Grüters, A., Biebermann, H., Brumm, Harald, Pitra, C., Gudermann, Thomas, Biebermann, Heike, Schöneberg, T., Schöneberg, Torsten, Römpler, H., Grüters, Annette   +17 more
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Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes [PDF]

, 2020
Human melanocortin MC1 and MC3 receptors expressed on C-20/A4 chondrocytes exhibit chondroprotective and anti-inflammatory effects when activated by melanocortin peptides.
De Pascale, C., Kerrigan, MJP, De Pascale, C, Grieco, P, Kerrigan, M.J.P., Grieco, P., Merlino, F, Can, V., Kaneva, MK, Getting, SJ, Merlino, F., Can, VC, Kaneva, M., Locke, IC, Locke, I.C., Getting, S.J.   +15 more
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Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source