Results 31 to 40 of about 32,241 (233)

Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]

, 2009
Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Kessler, L., Muller, Sylviane, Lecourt, Anne-Catherine, Bekel, Akkiz, Bekel, A., Zipfel, G., Peter, J. C., Kessler, Laurence, Eftekhari, Pierre, Eftekhari, P., Zipfel, Géraldine, Hofbauer, Karl G, Breidert, M., Breidert, Matthias, Lecourt, A. C., Muller, S., Nesslinger, Maya, Hofbauer, K. G., Nesslinger, M., Peter, Jean-Christophe   +19 more
core   +1 more source

Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells [PDF]

, 2011
Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex ...
Adrian J. L. Clark, Szidonya, L, Laszlo Szidonya, Cooray, SN, Mazhar, K, Teng-Teng Chung, Clark, AJ, Khansa Mazhar, Chung, TT, Sadani N. Cooray   +9 more
core   +1 more source

Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the ...
Shwetha Ramachandrappa, David S. Jackson, David eJackson, Adrian eClark, Li eChan, Shwetha eRamachandrappa, Ramachandrappa, S, Adrian J. Clark, Jackson, DS, Clark, AJ, Li F. Chan, Chan, LF   +11 more
core   +1 more source

The Asp84GIu variant of the melanocortin 1 receptor (MC1R)is associated with melanoma [PDF]

, 1996
Melanocyte stimulating hormone (MSH) plays an important role in determining the cutaneous response to ultraviolet radiation and may also influence melanoma progression.
Thody, Anthony J., Haldane, Faye, Jackson, Ian J., Jackson, Ian, Thody, Anthony J, Rees, Jonathan, Rees, Jonathan L., Sikkink, Stephen, Healy, Eugene, Carothers, Andrew, Valverde, Paloma   +10 more
core   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source

G-Protein-Coupled Receptors in Rheumatoid Arthritis: Recent Insights into Mechanisms and Functional Roles

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and even disability. Although there are various clinical therapies for RA, some patients still have poor or no response.
Jianan Zhao, Jianan Zhao, Jianan Zhao, Kai Wei, Kai Wei, Kai Wei, Ping Jiang, Ping Jiang, Ping Jiang, Cen Chang, Cen Chang, Cen Chang, Lingxia Xu, Lingxia Xu, Lingxia Xu, Linshuai Xu, Linshuai Xu, Linshuai Xu, Yiming Shi, Yiming Shi, Yiming Shi, Shicheng Guo, Shicheng Guo, Dongyi He, Dongyi He, Dongyi He, Dongyi He   +26 more
doaj   +1 more source

Melanocortin receptors in leptin effects [PDF]

Nature, 1997
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J., Yagaloff, Keith A., Fisher, Stewart L., Burn, Paul, Thiele, Todd E., Dijk, Gertjan van, Baskin, Denis G., Schwartz, Michael W.   +7 more
openaire   +3 more sources

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling

Frontiers in Endocrinology, 2016
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller, Lars Niederstadt, Wenke Jonas, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Annette Schürmann, Matthias Tschöp, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann   +16 more
doaj   +1 more source

Lateral septum as a melanocortin downstream site in obesity development

Cell Reports, 2023
Summary: The melanocortin pathway is well established to be critical for body-weight regulation in both rodents and humans. Despite extensive studies focusing on this pathway, the downstream brain sites that mediate its action are not clear.
Yuanzhong Xu, Zhiying Jiang, Hongli Li, Jing Cai, Yanyan Jiang, Joshua Otiz-Guzman, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong   +8 more
doaj   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources