Results 11 to 20 of about 32,241 (233)

The melanocortin receptors and their accessory proteins [PDF]

Frontiers in Endocrinology, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function. Since their identification almost 20 years ago much has been learnt about these receptors.
Ramachandrappa, S, Gorrigan, RJ, Clark, AJL, Chan, LF   +3 more
doaj   +9 more sources

Melanocortins, Melanocortin Receptors and Multiple Sclerosis [PDF]

Brain Sciences, 2017
The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis. This review discusses corticosteroid dependent and independent effects of melanocortins on the peripheral immune system ...
Robert P. Lisak, Joyce A. Benjamins
doaj   +5 more sources

MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors [PDF]

Journal of Molecular Endocrinology, 2014
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e.
Robert M, Dores, Richard L, Londraville, Jeremy, Prokop, Perry, Davis, Nathan, Dewey, Natalie, Lesinski   +5 more
openaire   +4 more sources

The Multifaceted Melanocortin Receptors [PDF]

Endocrinology, 2022
AbstractThe 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC2, these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that they have other poorly characterized functions.
Linda Laiho, Joanne Fiona Murray
openaire   +4 more sources

Observations on the Evolution of the Melanocortin Receptor Gene Family: Distinctive Features of the Melanocortin-2 Receptor [PDF]

Frontiers in Neuroscience, 2013
The melanocortin receptors (MCRs) are a gene family in the rhodopsin class of G protein-coupled receptors. Based on the analysis of several metazoan genome databases it appears that the MCRs are only found in chordates. The presence of five genes in the family (i.e., mc1r, mc2r, mc3r, mc4r, mc5r) in representatives of the tetrapods indicates that the ...
Robert Michael Dores
openaire   +4 more sources

The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives [PDF]

Frontiers in Endocrinology
The melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight ...
Claudia R. Prindle, Thomas L. Bennett, Benjamin H. Rajewski, Kade J. Kelley, Anna C. Impastato, Russell Potterfield, Daniel L. Marks, Jordan Y. Delev   +7 more
doaj   +2 more sources

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan   +14 more
doaj   +3 more sources

Cellular signatures of melanocortin pathway genes across the locus coeruleus [PDF]

Acta Neuropathologica Communications
Obesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD.
Alisha Basak, Fahrünisa Meryem Betül Erol, Maria Caterina De Rosa, Zhangji Dong, Victor Ogbolu, Hannah J. Glover, Rick Rausch, Gunnar Hargus, Jordi Creus-Muncunill, Heather Buchanan, Yu Bai, Qi Su, Betty Chang, Christina Adler, Delaney Flaherty, Benjamin Ciener, Harrison Xiao, Hasini Reddy, Pascaline Aime-Wilson, Christiane Reitz, Mark W. Sleeman, Judith Y. Altarejos, Rudolph L. Leibel, Liang Oscar Qiang, Andrew F. Teich, Claudia A. Doege   +25 more
doaj   +2 more sources

Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases [PDF]

Diseases
Melanocortin receptors (MCRs) are responsible for various functions ranging from skin pigmentation, regulation of appetite, stress response and cognition, steroid synthesis, and energy balance to cellular regeneration and immunomodulation.
Mainak Bardhan, Ayush Anand, Amaan Javed, Maria Andrea Chilo, Nida Khan, Tulika Garg, Arihant Surana, Helen Huang, M M Samim, Vinay Suresh, Abhinav Khare, Bindu Menon, Tithishri Kundu   +12 more
doaj   +2 more sources

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging [PDF]

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +2 more sources