Results 91 to 100 of about 23,013 (268)

Pain management after elective caesarean section under neuraxial anaesthesia: an updated systematic review and procedure‐specific postoperative pain management (PROSPECT) recommendations

Anaesthesia, EarlyView.
Summary Introduction Elective caesarean section is a common and painful procedure. Uncontrolled pain following caesarean section can profoundly and negatively on a wide range of patient and healthcare‐centred outcomes. The aim of this systematic review was to update existing recommendations for postoperative pain management after elective caesarean ...
Gillian Crowe, Benjamin Atterton, Eva Roofthooft, Girish P. Joshi, Narinder Rawal, Christopher Wu, Axel R. Sauter, Marie‐Pierre Bonnet, Dominique Nuala Lucas, Marc Van de Velde, on behalf of the PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy, Henrik Kehlet, Stephan M. Freys, Dileep N. Lobo, Eleni Moka, Neel Desai, Dario Bugada, Patricia Lavand'Homme, Helene Beloeil, Johan Raeder, Esther M. Pogatzki‐Zahn, Eric Albrecht, Geertrui Dewinter   +22 more
wiley   +1 more source

Quantum mechanics insights into melatonin and analogs binding to melatonin MT1 and MT2 receptors

Scientific Reports
Melatonin receptors MT1 and MT2 are G protein-coupled receptors that mediate the effects of melatonin, a hormone involved in circadian rhythms and other physiological functions.
Gabriela de Lima Menezes, Katyanna Sales Bezerra, Jonas Ivan Nobre Oliveira, John Fontenele Araújo, Douglas Soares Galvão, Roosevelt Alves da Silva, Marielena Vogel Saivish, Umberto Laino Fulco   +7 more
doaj   +1 more source

Critical care delirium: prevention, identification and management: a narrative review

Anaesthesia, EarlyView.
Summary Introduction Delirium is a frequent complication of critical illness and remains an important cause of short‐ and long‐term morbidity for patients admitted to ICUs. Delirium is associated with prolonged mechanical ventilation; extended ICU and hospital stay; and longer‐term health issues. Development is associated with patient (e.g.
Stephanie Kieswick, Ben Gibbison
wiley   +1 more source

Postoperative Sleep Interventions and Cardiac Surgery: A Systematic Review and Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Introduction Sleep disturbance is a common issue affecting nearly 78% of cardiothoracic postoperative patients. There are no systematic reviews of randomised controlled trials (RCTs) that evaluate the impact of sleep interventions within this population.
Alexander Lombardo, James Tsimiklis, Ammar Zaka, Alasdair Leslie, Brandon Stretton, Joshua Kovoor, Pramesh Kovoor, Stephen Bacchi, Aashray Gupta   +8 more
wiley   +1 more source

Melatonin receptor structure and signaling

Journal of Pineal Research
AbstractMelatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT1 and MT2 receptors are the best‐characterized. They are members of the G protein‐coupled receptor superfamily, preferentially coupling to Gi/o proteins but also ...
Okamoto, Hiroyuki, Cecon, Erika, Nureki, Osamu, Rivara, Silvia, Jockers, Ralf   +4 more
openaire   +4 more sources

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

World Journal of Gastroenterology, 2010
Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical ...
openaire   +2 more sources