Results 11 to 20 of about 23,013 (268)
Neurosignals, 1993 High-affinity melatonin receptors are expressed in the tail artery of the rat and arteries forming the circle of Willis of the rat and certain primates. The characteristics of the vascular melatonin receptors seem to be similar to the ones described in the central nervous system.
M, Viswanathan +2 more
openaire +2 more sources
Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway [PDF]
PeerJ, 2022 Background Melatonin, a neurohormone, maybe involved in physiological processes, such as antioxidation, anti-inflammation, and hair growth. In the present study, we investigated the effects of melatonin on proliferation and intracellular signaling in DP ...
Sowon Bae +6 more
doaj +2 more sources
Annals of Medicine, 1998 Melatonin is produced rhythmically by the pineal gland and the retina with increased synthesis during darkness. Pineal melatonin serves as the 'chemical expression of darkness' conveying information on the ambient light-dark cycle into rhythmic bodily functions.
T, Kokkola, J T, Laitinen
openaire +2 more sources
Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]
PLoS ONE, 2018 Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier +8 more
doaj +1 more source
Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses
BMC Oral Health, 2020 Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong +2 more
doaj +1 more source
Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. [PDF]
PLoS ONE, 2015 The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans.
Fanny Söderquist +2 more
doaj +1 more source
Melatonin signaling modulates clock genes expression in the mouse retina. [PDF]
PLoS ONE, 2014 Previous studies have shown that retinal melatonin plays an important role in the regulation of retinal daily and circadian rhythms. Melatonin exerts its influence by binding to G-protein coupled receptors named melatonin receptor type 1 and type 2 and ...
Susumu Hiragaki +5 more
doaj +1 more source
Melatonin, Melatonin Receptors and Melanophores: A Moving Story [PDF]
Pigment Cell Research, 2004 Melatonin (5‐methoxy N‐acetyltryptamine) is a hormone synthesized and released from the pineal gland at night, which acts on specific high affinity G‐protein coupled receptors to regulate various aspects of physiology and behaviour, including circadian and seasonal responses, and some retinal, cardiovascular and immunological functions.
Sugden, D +3 more
openaire +2 more sources
Journal of Advanced Research, 2022 Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well ...
Qianhui Sun +15 more
doaj +1 more source
Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice
Frontiers in Pharmacology, 2023 Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture ...
Tian-Ji Xia +12 more
doaj +1 more source