Results 21 to 30 of about 23,013 (268)

Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus

Journal of Circadian Rhythms, 2015
The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control.
Nermien Waly, Richard Hallworth
doaj   +1 more source

The role of melatonin in diabetes: therapeutic implications

Archives of Endocrinology and Metabolism, 2015
Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2).
Shweta Sharma, Hemant Singh, Nabeel Ahmad, Priyanka Mishra, Archana Tiwari   +4 more
doaj   +1 more source

Melatonin in Male Dromedary Camel (Camelus dromedarius) Seminal Plasma and Its Specific MT1 and MT2 Receptors on Sperm Membranes

Animals
Camels (Camelus dromedarius) are seasonal short-day breeders, regulated by photoperiod and melatonin secretion. However, no studies have explored melatonin levels in camel seminal plasma or their relationship with testosterone, age, or climatic factors ...
Lamia Doghbri, Melissa Carvajal-Serna, Moufida Atigui, Adriana Casao, Victoria Peña-Delgado, Mabrouk-Mouldi Seddik, Mohamed Dbara, Rosaura Pérez-Pé, Mohamed Hammadi   +8 more
doaj   +1 more source

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

Scientific Reports, 2017
Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61,
Atsuro Oishi, Angeliki Karamitri, Romain Gerbier, Olivier Lahuna, Raise Ahmad, Ralf Jockers   +5 more
doaj   +1 more source

Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells

Brazilian Journal of Medical and Biological Research, 2005
The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embryonic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells
L.F.S. Sampaio, D.E. Hamassaki-Britto, R.P. Markus   +2 more
doaj   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Dampening of neurotransmitter action: molecular similarity within the melatonin structure

Endocrine Regulations, 2018
Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
doaj   +1 more source

Preliminary Evaluation of Human Gingiva as an Extrapineal Site of Melatonin Biosynthesis in States of Periodontal Health and Disease [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Melatonin is a pineal gland hormone that plays an important role in periodontal homeostasis. Extra pineal melatonin production has been found to occur in tissues like the ovaries, retina and gastrointestinal tract.
Balaji Thodur Madapusi, Suresh Ranga Rao
doaj   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Is Melatonin the Cornucopia of the 21st Century?

Antioxidants, 2020
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) and regulating the sleep/wake cycle in humans.
Nadia Ferlazzo, Giulia Andolina, Attilio Cannata, Maria Giovanna Costanzo, Valentina Rizzo, Monica Currò, Riccardo Ientile, Daniela Caccamo   +7 more
doaj   +1 more source