Results 91 to 100 of about 81,074 (260)

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

Shedding Light on Metabotropic Glutamate Receptors [PDF]

Cell Chemical Biology, 2016
In this issue of Cell Chemical Biology, the elegant manuscript by Rovira et al. (2016) describes a negative allosteric modulator (NAM) of mGlu4 metabotropic glutamate receptors with in vivo activity. This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their ...
openaire   +3 more sources

Membrane Topology of a Metabotropic Glutamate Receptor [PDF]

Journal of Biological Chemistry, 2003
The metabotropic glutamate receptors (mGluRs) have been predicted to have a classical seven transmembrane domain structure similar to that seen for members of the G-protein-coupled receptor (GPCR) superfamily. However, the mGluRs (and other members of the family C GPCRs) show no sequence homology to the rhodopsin-like GPCRs, for which this seven ...
Ruchir D. Shah, D. J. Brasier, Stephen F. Heinemann, Gautam Bhave, Kathi S. Glauner, Robert W. Gereau, Brian M. Nadin, Farzana Karim   +7 more
openaire   +3 more sources

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

Scientific Reports, 2015
The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. They are among the most highly pursued drug targets, with relevance for several neurological diseases and a number of allosteric modulators have
K. Harpsøe, Vignir Ísberg, B. Tehan, Dahlia R. Weiss, Angela Arsova, F. Marshall, H. Bräuner‐Osborne, David E. Gloriam   +7 more
semanticscholar   +1 more source

Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons

Frontiers in Cellular Neuroscience, 2021
The cellular mechanisms regulating dopamine (DA) release in the striatum have attracted much interest in recent years. By in vitro amperometric recordings in mouse striatal slices, we show that a brief (5 min) exposure to the metabotropic glutamate ...
Nicola B. Mercuri, Nicola B. Mercuri, Mauro Federici, Francesca Romana Rizzo, Lorenzo Maugeri, Sebastian L. D’Addario, Sebastian L. D’Addario, Sebastian L. D’Addario, Rossella Ventura, Rossella Ventura, Nicola Berretta   +10 more
doaj   +1 more source

Quantifying constraints determining independent activation on NMDA receptors mediated currents from evoked and spontaneous synaptic transmission at an individual synapse [PDF]

arXiv, 2022
A synapse acts on neural transmission through a chemical process called synapses fusion between pre-synaptic and post-synaptic terminals. Presynaptic terminals release neurotransmitters either in response to action potential or spontaneously independent of presynaptic activity.
arxiv  

Metabotropic glutamate receptors: Phosphorylation and receptor signaling

Journal of Neuroscience Research, 2007
AbstractMetabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of ...
Jinu Lee, Katherine W. Roche, Jae-Youn Lee, Chul Hoon Kim   +3 more
openaire   +3 more sources

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors*

Journal of Biological Chemistry, 2015
Background: Transient rise of extracellular glutamate occurs in the developing brain. Results: Glutamate stimulates axonal translation by binding to AMPA receptors and metabotropic glutamate receptors and activating Ca2+ and mTOR signaling.
Wei-Lun 瑋倫 Hsu 許, Hui-Wen 惠雯 Chung 鍾, Chih-Yueh 芝岳 Wu 巫, Huei-Ing 慧音 Wu 吳, Yu-Tao 侑道 Lee 李, En-Chan 恩湛 Chen 陳, Weilun 維倫 Fang 方, Yen-Chung 兗君 Chang 張   +7 more
semanticscholar   +1 more source

The Hippocampus Is the Place to Be: Opioid Receptors and LTP

Cell Reports, 2019
Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson, John Georgiou, Patrick Tidball, Graham L. Collingridge   +3 more
doaj