Results 131 to 140 of about 108,504 (259)

Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery

JOR SPINE, Volume 8, Issue 3, September 2025.
This study explores the role of Central Pattern Generators (CPGs) in locomotor recovery after spinal cord injury (SCI). It examines CPG organization, function, and modulation through amino acids, biogenic amines, and acetylcholine. Therapeutic strategies, including pharmacological, electrical, and optogenetic approaches, are reviewed, alongside current
Hao Su, Longfei Jing, Dongmei Lv, Zhendong Huan, Wenqiang Xu   +4 more
wiley   +1 more source

Astrocytes Control Neuronal Excitability in the Nucleus Accumbens

The Scientific World Journal, 2007
Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood.
Tommaso Fellin, Marcello D'Ascenzo, Philip G. Haydon   +2 more
doaj   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, Volume 45, Issue 5, Page 1307-1322, September 2025.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Conformational diversity in class C GPCR positive allosteric modulation

Nature Communications
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon   +11 more
doaj   +1 more source

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Wei-ye Chen, Xi-jun Wang, Jin-ying Ge, Xijun He, Z. Wen, Z. Bu   +12 more
semanticscholar   +1 more source

Selective Effects of Acutely Administered N‐Acetyl‐Cysteine in Rodent Models of Nicotine‐Conditioned Behaviours

Addiction Biology, Volume 30, Issue 9, September 2025.
ABSTRACT Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro‐drug, N‐acetyl‐cysteine (NAC), is a promising glutamatergic agent that has shown some clinical efficacy in reducing nicotine use in humans.
Kelsey Stoddart, Michael Davies, Jamie Oughton, Emma Malcolm, Shakir D. AlSharari, Mohammed Shoaib   +5 more
wiley   +1 more source

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors

Molecules, 2019
Metabotropic glutamate (mGlu) receptors are a family of eight GPCRs that are attractive drug discovery targets to modulate glutamate action and response. Here we review the application of computational methods to the study of this family of receptors.
Claudia Llinas del Torrent, Laura Pérez-Benito, Gary Tresadern   +2 more
doaj   +1 more source

Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship With Neurotransmitter and Gene Expression Profiles

Human Brain Mapping, Volume 46, Issue 12, 15 August 2025.
By harmonizing resting‐state fMRI data from a relatively large multi‐site sample, this study reveals altered modular dynamics in schizophrenia. These alterations are associated with multiple neurotransmitter systems and transcriptomic profiles that are preferentially enriched for biological processes of transmembrane transport and brain development, as
Yi Zhen, Yaqian Yang, Yi Zheng, Zhiming Zheng, Hongwei Zheng, Shaoting Tang   +5 more
wiley   +1 more source

Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration

Receptors
The retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic ...
Bolaji Oyetayo, Yurixy Mendoza-Silva, Temitayo Subair, Luisa C Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Tatiana N. Olivares-Bañuelos, Arturo Ortega   +6 more
doaj   +1 more source

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

Frontiers in Molecular Neuroscience, 2018
Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease,
Md. Jakaria, Shin-Young Park, Md. Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Palanivel Ganesan, Dong-Kug Choi, Dong-Kug Choi, Dong-Kug Choi   +9 more
doaj   +1 more source