Results 151 to 160 of about 81,074 (260)

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors

Molecules, 2019
Metabotropic glutamate (mGlu) receptors are a family of eight GPCRs that are attractive drug discovery targets to modulate glutamate action and response. Here we review the application of computational methods to the study of this family of receptors.
Claudia Llinas del Torrent, Laura Pérez-Benito, Gary Tresadern   +2 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide Orchestrates Neuronal Regulation Of The Astrocytic Glutamate-Releasing Mechanism System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e [PDF]

, 2016
Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes. Hence, it is critical to better understand how neurons and astrocytes interact to coordinate the cellular regulation of glutamate signaling.
Albano, Rebecca, Baker, David A., Choi, Sujean, Kong, Linghai, Lobner, Doug, Madayag, Aric, Mantsch, John R., Raddatz, Nicholas   +7 more
core   +1 more source

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control

Journal of Neuroendocrinology, EarlyView.
Abstract Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP‐producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re‐evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r.
Limei Zhang, Vito Salvador Hernández, Mario Alberto Zetter, Oscar Rene Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Lee E. Eiden, Robert P. Millar   +7 more
wiley   +1 more source

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

Neurobiology of Disease, 1999
Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez, Carlos Matute   +1 more
doaj  

In-vivo Magnetic Resonance Imaging of GABA and Glutamate [PDF]

arXiv, 2020
Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is a molecular imaging methodology capable of mapping brain metabolites with relatively high spatial resolution. Specificity is the main goal of such experiments; yet CEST is confounded by spectral overlap between different molecular species.
arxiv  

On the mechanisms of brain blood flow regulation during hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of key hypothesized mechanisms mediating the cerebrovascular response to hypoxia, suggested by the results of studies included in this analysis. Abstract The brain requires an uninterrupted supply of oxygen and nutrients to support the high metabolic needs of billions of nerve cells processing information ...
Alexander Mascarenhas, Alice Braga, Sara Maria Majernikova, Shereen Nizari, Debora Marletta, Shefeeq M. Theparambil, Qadeer Aziz, Nephtali Marina, Alexander V. Gourine   +8 more
wiley   +1 more source

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Wei-ye Chen, Xi-jun Wang, Jin-ying Ge, Xijun He, Z. Wen, Z. Bu   +12 more
semanticscholar   +1 more source

Conformational diversity in class C GPCR positive allosteric modulation

Nature Communications
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon   +11 more
doaj   +1 more source

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Shailesh Banerjee, Theodore Lidsky   +5 more
core   +1 more source

Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders

The Journal of Physiology, EarlyView.
Abstract figure legend The carotid body develops aberrant high activity in chronic heart failure, resistant hypertension, obstructive sleep apnoea (OSA) and diabetes. Hyperactivity of the carotid body leads to both high tonicity and increased sensitivity of the arterial chemoreflex with resultant sympathoexcitation.
Tymoteusz Żera, Bartłomiej Paleczny, Maciej Siński, Sílvia V. Conde, Krzysztof Narkiewicz, Piotr Ponikowski, Julian F.R. Paton, Piotr Niewiński   +7 more
wiley   +1 more source