Results 211 to 220 of about 108,504 (259)

Non-canonical Roles of Complement in the CNS: From Synaptic Organizer to Presynaptic Modulator of Glutamate Transmission. [PDF]

Curr Neuropharmacol
Pittaluga A, Torre V, Olivero G, Rosenwasser N, Taddeucci A.   +4 more
europepmc   +1 more source

ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri.

J Exp Biol
Ho VR, Goss GG, Leys SP.
europepmc   +1 more source

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Pharmacology and functions of metabotropic glutamate receptors.

Annual Review of Pharmacology and Toxicology, 1997
▪ Abstract  In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins. Since those initial reports, tremendous progress has been made in characterizing these metabotropic glutamate ...
Conn Pj, J. Pin
semanticscholar   +4 more sources

International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors

Pharmacological Reviews, 2020
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for higher-order brain functions such as learning and memory.
K. Gregory, C. Goudet
semanticscholar   +1 more source

The metabotropic glutamate receptors: Structure and functions

Neuropharmacology, 1995
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via ...
J. Pin, R. Duvoisin
semanticscholar   +3 more sources

Dynamics and modulation of metabotropic glutamate receptors.

Current Opinion in Pharmacology, 2015
The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
P. Rondard, J. Pin
semanticscholar   +4 more sources

Metabotropic glutamate receptors

Cell and Tissue Research, 2006
Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
openaire   +3 more sources