Cell Death and Disease, 2021 Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor ...
Julian P. Maier +17 more
doaj +1 more source
A mechanistic overview of approaches for the treatment of psychostimulant dependence
Frontiers in Pharmacology, 2022 Psychostimulant use disorder is a major health issue around the world with enormous individual, family-related and societal consequences, yet there are no effective pharmacological treatments available.
Kathrine Louise Jensen +2 more
doaj +1 more source
Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]
, 2017 Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K. +4 more
core +2 more sources
Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
Frontiers in Molecular Neuroscience, 2019 Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve injury is long lasting and responsible for long-term disability in ...
Vanessa Pereira, C. Goudet
semanticscholar +1 more source
Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release
Frontiers in Molecular Neuroscience, 2018 A metabotropic modus operandi for kainate receptors (KARs) was first discovered in 1998 modulating GABA release. These receptors have been also found to modulate glutamate release at different synapses in several brain regions. Mechanistically, a general
José V. Negrete-Díaz +4 more
doaj +1 more source
Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]
, 2010 Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa +11 more
core +2 more sources
Journal of Experimental Medicine, 2018 Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade.
C. Kaittanis +16 more
semanticscholar +1 more source
Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Frontiers in Molecular Neuroscience, 2018 Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that finally lead to slow neuronal degeneration and death. Although neurons are the principal target, glial cells are important players as they contribute by either ...
S. Spampinato +4 more
semanticscholar +1 more source
Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics
Biomedical and Biotechnology Research Journal, 2021 Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic
Shree Goyal +2 more
doaj +1 more source
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Molecular Brain, 2017 Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease.
James Maksymetz +2 more
semanticscholar +1 more source