Results 1 to 10 of about 2,325,434 (292)
Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague–Dawley rats [PDF]
Physiological ReportsIn the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates the stress ...
D. Sztechman +4 more
doaj +2 more sources
Localization of mineralocorticoid receptors at mammalian synapses. [PDF]
PLoS ONE, 2010 In the brain, membrane associated nongenomic steroid receptors can induce fast-acting responses to ion conductance and second messenger systems of neurons.
Eric M Prager +4 more
doaj +2 more sources
Environment International, 2019 Endocrine-disrupting chemicals (EDCs) have received significant concern, since they ubiquitously exist in the environment and are able to induce adverse health effects on human and wildlife. Increasing evidence shows that the glucocorticoid receptor (GR)
Jianyun Zhang, Ye Yang, Weiping Liu
exaly +3 more sources
Mineralocorticoid Receptor Antagonists [PDF]
International Cardiovascular Forum Journal, 2019 Two mineralocorticoid receptor antagonists, spironolactone and eplerenone, are currently approved by the FDA. Several non-steroid based ligands are in clinical trials for indications including heart failure, hypertension and diabetic kidney disease, and even more structurally distinct chemical series are reported in the literature with preclinical data
Anneli, Nordqvist, Kenneth L, Granberg
+5 more sources
Pharmaceutics, 2023 Tacrolimus (Tac) is a calcineurin inhibitor commonly used as an immunosuppressor after solid organ transplantation. However, Tac may induce hypertension, nephrotoxicity, and an increase in aldosterone levels.
Stefanny M. Figueroa +5 more
doaj +1 more source
Cardiorenal benefits of finerenone: protecting kidney and heart
Annals of Medicine, 2023 Persons with diabetes and chronic kidney disease (CKD) have a high residual risk of developing cardiovascular (CV) complications despite treatment with renin-angiotensin system blockers and sodium-glucose cotransporter type 2 inhibitors.
José R. González-Juanatey +5 more
doaj +1 more source
Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study [PDF]
PeerJ, 2018 Background Past findings support a relationship between abnormalities in the amygdala and the presence of psychopathic traits. Among other genes and biomarkers relevant to the amygdala, norepinephrine and mineralocorticoid receptors might both play a ...
Guillaume Durand
doaj +2 more sources
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor mutations [PDF]
Journal of Endocrinology, 2017 Aldosterone and the mineralocorticoid receptor (MR) are key elements for maintaining fluid and electrolyte homeostasis as well as regulation of blood pressure. Loss-of-function mutations of the MR are responsible for renal pseudohypoaldosteronism type 1 (PHA1), a rare disease of mineralocorticoid resistance presenting in the newborn with weight loss ...
Maria-Christina, Zennaro +1 more
openaire +2 more sources
New Perspectives on Sex Steroid and Mineralocorticoid Receptor Signaling in Cardiac Ischemic Injury
Frontiers in Physiology, 2022 The global burden of ischemic heart disease is burgeoning for both men and women. Although advances have been made, the need for new sex-specific therapies targeting key differences in cardiovascular disease outcomes in men and women remains ...
Laura A. Bienvenu +7 more
doaj +1 more source
Pseudohypoaldosteronism Type 1 with a Novel Mutation in the Gene: A Case Report [PDF]
Childhood Kidney Diseases, 2020 Pseudohypoaldosteronism type 1 (PHA1) is a rare salt-wasting disorder caused by resistance to mineralocorticoid action. PHA1 is of two types with different levels of disease severity and phenotype as follows: systemic type with an autosomal recessive ...
Young Min Kim +4 more
doaj +1 more source