Results 11 to 20 of about 18,286 (260)
Aldosterone Blocks Rat Stem Leydig Cell Development In Vitro
Frontiers in Endocrinology, 2018 Aldosterone (ALDO) is a primary endogenous mineralocorticoid, appearing as the main hormone controlling sodium and water homeostasis. Its emerging role in the development of many organs has gained interest over the past few years.
Jingwei Zhang +9 more
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Evolution of ligand specificity in vertebrate corticosteroid receptors
BMC Evolutionary Biology, 2011 Background Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors. Teleost fishes have a single MR and duplicate GRs that show variable sensitivities to mineralocorticoids and glucocorticoids.
Deitcher David L +6 more
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30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature [PDF]
Journal of Endocrinology, 2017 Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism ...
Jennifer J, DuPont, Iris Z, Jaffe
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Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
PLoS ONE, 2014 The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson +2 more
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Pseudohypoaldosteronism Type I: A Report of Two Cases
Endocrinology Research and Practice, 2022 Pseudohypoaldosteronism (PHA) i s characterised by salt wasting and failure to thrive in the newborn because of the resistance of mineralocorticoid receptors to aldosterone.
Enver Şimşek, Kenan Kocabay
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Mineralocorticoid receptors guide spatial and stimulus-response learning in mice. [PDF]
PLoS ONE, 2014 Adrenal corticosteroid hormones act via mineralocorticoid (MR) and glucocorticoid receptors (GR) in the brain, influencing learning and memory. MRs have been implicated in the initial behavioral response in novel situations, which includes behavioral ...
J Marit Arp +6 more
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PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY
Рациональная фармакотерапия в кардиологии, 2017 The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
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Comparison of stress-induced changes in adults and pups: is aldosterone the main adrenocortical stress hormone during the perinatal period in rats? [PDF]
PLoS ONE, 2013 Positive developmental impact of low stress-induced glucocorticoid levels in early development has been recognized for a long time, while possible involvement of mineralocorticoids in the stress response during the perinatal period has been neglected ...
János Varga +5 more
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Терапевтический архив, 2023 The renin-angiotensin-aldosterone system (RAAS) activation plays a key role in the chronic kidney disease (CKD) progression and in the cardiovascular complications (CVC) development in patients with diabetes mellitus (DM).
Irina N. Bobkova
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Mineralocorticoid Receptor Antagonists in ESKD [PDF]
Clinical Journal of the American Society of Nephrology, 2020 There is an urgent need for interventions that reduce cardiovascular risks in patients with ESKD. Recently there has been considerable interest in whether blocking the effects of the mineralocorticoid aldosterone could be such an intervention.
Adhish, Agarwal, Alfred K, Cheung
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