Results 21 to 30 of about 2,325,434 (292)
Endocrinology, 2019 Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals.
C. Rivers +5 more
semanticscholar +1 more source
Терапевтический архив, 2023 The renin-angiotensin-aldosterone system (RAAS) activation plays a key role in the chronic kidney disease (CKD) progression and in the cardiovascular complications (CVC) development in patients with diabetes mellitus (DM).
Irina N. Bobkova
doaj +1 more source
PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY
Рациональная фармакотерапия в кардиологии, 2017 The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj +1 more source
Comparison of stress-induced changes in adults and pups: is aldosterone the main adrenocortical stress hormone during the perinatal period in rats? [PDF]
PLoS ONE, 2013 Positive developmental impact of low stress-induced glucocorticoid levels in early development has been recognized for a long time, while possible involvement of mineralocorticoids in the stress response during the perinatal period has been neglected ...
János Varga +5 more
doaj +1 more source
Aldosterone and Mineralocorticoid Receptors—Physiology and Pathophysiology
International Journal of Molecular Sciences, 2017 Aldosterone is a uniquely terrestrial hormone, first appearing in lungfish, which have both gills and lungs. Mineralocorticoid receptors (MRs), on the other hand, evolved much earlier, and are found in cartilaginous and bony fish, presumptive ligand ...
J. Funder
semanticscholar +1 more source
Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology
International Journal of Molecular Sciences, 2018 The nuclear hormone receptor (NR) superfamily comprises approximately 50 evolutionarily conserved proteins that play major roles in gene regulation by prototypically acting as ligand-dependent transcription factors.
L. Sevilla, P. Pérez
semanticscholar +1 more source
Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension
Pulmonary Circulation, 2021 Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon +10 more
doaj +1 more source
Aldosterone: Essential for Life but Damaging to the Vascular Endothelium
Biomolecules, 2023 The renin angiotensin aldosterone system is a key regulator of blood pressure. Aldosterone is the final effector of this pathway, acting predominantly via mineralocorticoid receptors. Aldosterone facilitates the conservation of sodium and, with it, water
Michael Crompton +3 more
doaj +1 more source
Science Signaling, 2017 Analysis of the interactions of multiple steroid ligands with the mineralocorticoid receptor identifies domains involved in activation and inhibition. Evolving steroid responses Mineralocorticoid receptors (MRs) are members of the nuclear receptor family
Y. Katsu, Kaori Oka, M. Baker
semanticscholar +1 more source
The role of aldosterone in the development of atrial fibrillation: modern understanding of problem
Архивъ внутренней медицины, 2019 The review of literature presents modern ideas about the role of aldosterone in the development and maintenance of atrial fibrillation. It is shown that hormone takes part in all stages of the electrophysiological and structural atrial remodeling ...
N. T. Vatutin +2 more
doaj +1 more source