Results 111 to 120 of about 83,236 (271)

Efficacy of ASA Therapy After Desensitization on CRSwNP Patients With Asthma and N‐ERD—A Randomized Clinical Trial

Allergy, EarlyView.
This randomized double‐blind clinical trial investigated the impact of aspirin therapy after desensitization in patients with CRSwNP, asthma, and N‐ERD. Various clinical outcomes were assessed, including health‐related quality of life (with the SNOT‐22 questionnaire) and the severity of nasal polyposis (with the NPS).
Alma Helevä, Annina Lyly, Viljami Salmi, Mika Mäkelä, Paula Kauppi, Anu Laulajainen‐Hongisto, Lena Hafrén, Paula Virkkula, Mikko Nuutinen, Sanna Toppila‐Salmi   +9 more
wiley   +1 more source

Allosteric Modulation of Muscarinic Acetylcholine Receptors

Pharmaceuticals, 2010
An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonist (e.
Esam E. El-Fakahany, Jan Jakubík
doaj   +1 more source

The Danger to the Chemical Weapons Convention from Incapacitating Chemicals [PDF]

, 2003
Ye
Dando, Malcolm R.
core  

Fungal‐Driven Airways Dis‐Immunity From Asthma to Allergic Bronchopulmonary Aspergillosis: Dissecting Similarities and Differences

Allergy, EarlyView.
ABSTRACT Severe asthma and allergic bronchopulmonary aspergillosis (ABPA) do not rarely coexist and share several similarities in terms of pathobiological background, together with overlapping clinical manifestations, misleading the correct diagnosis. Within that scenario, severe asthma with fungal sensitization (SAFS) further complicates the correct ...
Marco Caminati, Isabella Annesi‐Maesano, Wojciech Feleszko, Giuseppe Guida, Christer Janson, Shadi Hägg, Andrei Malinovschi, Luciana Tanno, Joana Vitte, Francesca Ambrosani, Matteo Maule   +10 more
wiley   +1 more source

Cardiac muscarinic receptor overexpression in sudden infant death syndrome.

PLoS ONE, 2010
BackgroundSudden infant death syndrome (SIDS) remains the leading cause of death among infants less than 1 year of age. Disturbed expression of some neurotransmitters and their receptors has been shown in the central nervous system of SIDS victims but no
Angelo Livolsi, Nathalie Niederhoffer, Nassim Dali-Youcef, Caroline Rambaud, Catherine Olexa, Walid Mokni, Jean-Pierre Gies, Pascal Bousquet   +7 more
doaj   +1 more source

Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits

Allergy, EarlyView.
AHR improves in most children over adolescence when its relationship with asthma changes. AHR is better at ruling out asthma in children, while it is superior at ruling in asthma in young adults. Age should be considered when interpreting AHR, and different cutoffs might be required for children and adults.
Sophie Carra, Hongmei Zhang, Ramesh J. Kurukulaaratchy, Syed Hasan Arshad   +3 more
wiley   +1 more source

Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress

Data in Brief, 2016
We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2],
Ravirajsinh N. Jadeja, Nathalie H. Urrunaga, Daniel Ahmad, Sandeep Khurana   +3 more
doaj   +1 more source

Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

Frontiers in Cellular Neuroscience, 2019
The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing
Viktoriya Morozova, Viktoriya Morozova, Leah S. Cohen, Ali El-Hadi Makki, Alison Shur, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Abdeslem El Idrissi, Alejandra D. Alonso, Alejandra D. Alonso   +10 more
doaj   +1 more source

Muscarinic receptors and ligands in cancer

American Journal of Physiology-Cell Physiology, 2009
Emerging evidence indicates that muscarinic receptors and ligands play key roles in regulating cellular proliferation and cancer progression. Both neuronal and nonneuronal acetylcholine production results in neurocrine, paracrine, and autocrine promotion of cell proliferation, apoptosis, migration, and other features critical for cancer cell survival ...
Kunrong Cheng, Jean-Pierre Raufman, Nirish Shah, Sandeep Khurana   +3 more
openaire   +4 more sources

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source