Results 111 to 120 of about 2,302,872 (259)

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Nature, 2016
D. Thal, Bingfa Sun, D. Feng, Vindhya Nawaratne, K. Leach, C. Felder, M. Bures, David A. Evans, W. Weis, P. Bachhawat, T. S. Kobilka, P. Sexton, B. Kobilka, A. Christopoulos   +13 more
semanticscholar   +1 more source

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, EarlyView.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

Studying the Role of Myenteric Amyloidosis in Gastrointestinal Dysmotility and Enteric Neural Dysfunction Using APP/PS1 Mice—Is It an Adequate Animal Model?

Neurogastroenterology &Motility, EarlyView.
Amyloidosis in the central and enteric nervous system contributes to cognitive deficits and gastrointestinal dysmotility—the constipation in Alzheimer's disease (AD). APP/PS1 mice, a transgenic mouse model of amyloidosis, recapitulated the amyloidosis in the central nervous system; they were unsustainable in recapitulating the amyloidosis in the ...
Roxanne Fernandes, Marlene Masino, Emma Flood, Theresa A. Lansdell, Nikitha Srikrishna, Ryan Mui, Anne M. Dorrance, James J. Galligan, Hui Xu   +8 more
wiley   +1 more source

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts

Brain, Behavior, & Immunity - Health, 2020
Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist   +5 more
doaj  

Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data

Oral Diseases, EarlyView.
ABSTRACT Objective Neuropsychiatric disorders are associated with poor oral health, with antipsychotics as potential contributors. This study aimed to analyse the oral adverse effects of antipsychotics using the EudraVigilance database. Methods A case/noncase analysis was conducted to calculate reporting odds ratios (ROR) and assess the ...
Leire Urien, Unax Lertxundi, Montserrat Garcia, Carmelo Aguirre, Nerea Jauregizar, Teresa Morera‐Herreras   +5 more
wiley   +1 more source

Neuroimmune pathophysiology of long COVID

Psychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen, Christopher A. Baker, Akiko Iwasaki   +2 more
wiley   +1 more source

Mapping Bullous Emphysema With Lung Ultrasound: A Prospective Multicentre Study

Respirology, EarlyView.
ABSTRACT Background and Objectives Lung ultrasound holds high diagnostic performance for pleural diseases, notably pneumothorax. Bullous emphysema is a potential differential diagnosis of pneumothorax on ultrasound, but its precise semiology is poorly known.
Kinan El Husseini, Thomas Flament, Sophie Laroumagne, Damien Basille, Mathilde Le Brun, Elise Noël‐Savina, Philippe Richard, Gilles Mangiapan, Elise Artaud‐Macari   +8 more
wiley   +1 more source

Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy

Journal of Clinical Investigation, 2017
N. Calcutt, Darrell R. Smith, Katie Frizzi, M. Sabbir, S. R. Chowdhury, T. Mixcoatl-Zecuatl, A. Saleh, Nabeel Muttalib, Randy Van der Ploeg, Joseline Ochoa, A. Gopaul, Lori Tessler, J. Wess, C. Jolivalt, P. Fernyhough   +14 more
semanticscholar   +1 more source

Intraocular Pressure Increase Induced by 0.5% Tropicamide‐0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy

Veterinary Ophthalmology, EarlyView.
ABSTRACT Purpose To determine whether the differences in intraocular pressure (IOP) change after the topical application of 0.5% tropicamide and 0.5% phenylephrine (TP) are due to anatomical variations in the anterior chamber using ultrasound biomicroscopy (UBM).
Donghee Kim, Sang‐Eun Park, Haerin Yoon, Jiyi Hwang, Ji Seung Jung, Soohyun Kim, Kyung‐Mee Park   +6 more
wiley   +1 more source

Muscarinic acetylcholine receptors: novel opportunities for drug development

Nature reviews. Drug discovery, 2014
A. Kruse, B. Kobilka, D. Gautam, P. Sexton, A. Christopoulos, J. Wess   +5 more
semanticscholar   +1 more source