Results 31 to 40 of about 155,151 (336)

Polyglutamine-expanded Huntingtin Promotes Sensitization of N-Methyl-d-aspartate Receptors via Post-synaptic Density 95*

Journal of Biological Chemistry, 2001
Increased glutamate-mediated excitotoxicity seems to play an important role in the pathogenesis of Huntington's disease (Tabrizi, S. J., Cleeter, M. W., Xuereb, J., Taaman, J. W., Cooper, J. M., and Schapira, A. H. (1999)Ann. Neurol. 45, 25–32). However,
Y. Sun, Anneli Savanenin, P. Reddy, Y. Liu   +3 more
semanticscholar   +1 more source

Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke

Brain, Behavior, & Immunity - Health, 2023
Background: Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic ...
Pia S. Sperber, Pimrapat Gebert, Leonie H.A. Broersen, Anna Kufner, Shufan Huo, Sophie K. Piper, Bianca Teegen, Peter U. Heuschmann, Harald Prüss, Matthias Endres, Thomas G. Liman, Bob Siegerink   +11 more
doaj   +1 more source

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

Development and characterization of functional antibodies targeting NMDA receptors

Nature Communications, 2022
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders.
Nami Tajima, Noriko Simorowski, Remy A. Yovanno, Michael C. Regan, Kevin Michalski, Ricardo Gómez, Albert Y. Lau, Hiro Furukawa   +7 more
doaj   +1 more source

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Anti-N-Methyl-d-Aspartate Receptor Encephalitis

Pediatrics & Neonatology, 2011
Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a treatment-responsive encephalitis associated with anti-NMDA receptor antibodies, which bind to the NR1/NR2 heteromers of the NMDA receptors. It is a highly characteristic syndrome evolving in five stages: the prodromal phase (viral infection-like symptoms), psychotic phase, unresponsive phase,
Te-Yu Hung, Ning-Hui Foo, Ming-Chi Lai
openaire   +3 more sources

Cardiac N-methyl d-aspartate Receptors as a Pharmacological Target [PDF]

Journal of Cardiovascular Pharmacology, 2016
Abstract: This study focuses on characterization of the cardiac N-methyl d-aspartate receptors (NMDARs) as a target for endogenous and synthetic agonists and antagonists. Using isolated perfused rat hearts, we have shown that intracoronary administration of the NMDAR agonists and antagonists has a pronounced effect on autonomous heart ...
Makhro, Asya, Tian, Qinghai, Kaestner, Lars, Kosenkov, Dmitry, Faggian, Giuseppe, Gassmann, Max, Schwarzwald, Colin, Bogdanova, Anna   +7 more
openaire   +4 more sources

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

Journal of Pharmacological Sciences, 2022
N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine).
Tomohiko Irie, Yuta Yanase, Yosuke Demizu, Makoto Usami, Ruri Kikura-Hanajiri   +4 more
doaj   +1 more source

N-methyl-D-aspartate receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunit delta2 mutant mice. [PDF]

, 2005
Classical eyeblink conditioning has been known to depend critically on the cerebellum. Apparently consistent with this, glutamate receptor subunit delta2 null mutant mice, which have serious morphological and functional deficiencies in the cerebellar ...
Fukunaga Satoshi, Kato Yoshiko, Kawahara Shigenori, Kirino Yutaka, Mishina Masayoshi, Mori Hisashi, Takatsuki Kanako   +6 more
core   +2 more sources

Neuron-derived D-Serine Release Provides a Novel Means to Activate N-Methyl-D-aspartate Receptors*

Journal of Biological Chemistry, 2006
d-Serine is a coagonist of N-methyl-d-aspartate (NMDA) receptors that occurs at high levels in the brain. Biosynthesis of d-serine is carried out by serine racemase, which converts l-to d-serine.
Elena Kartvelishvily, M. Shleper, L. Balan, E. Dumin, Herman Wolosker   +4 more
semanticscholar   +1 more source