Results 31 to 40 of about 115,612 (189)

Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke

Brain, Behavior, & Immunity - Health, 2023
Background: Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic ...
Pia S. Sperber, Pimrapat Gebert, Leonie H.A. Broersen, Anna Kufner, Shufan Huo, Sophie K. Piper, Bianca Teegen, Peter U. Heuschmann, Harald Prüss, Matthias Endres, Thomas G. Liman, Bob Siegerink   +11 more
doaj   +1 more source

Development and characterization of functional antibodies targeting NMDA receptors

Nature Communications, 2022
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders.
Nami Tajima, Noriko Simorowski, Remy A. Yovanno, Michael C. Regan, Kevin Michalski, Ricardo Gómez, Albert Y. Lau, Hiro Furukawa   +7 more
doaj   +1 more source

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

Journal of Pharmacological Sciences, 2022
N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine).
Tomohiko Irie, Yuta Yanase, Yosuke Demizu, Makoto Usami, Ruri Kikura-Hanajiri   +4 more
doaj   +1 more source

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev, A Sali, A Villarroel, AI Sobolevskii, AI Sobolevsky, AI Sobolevsky, AI Sobolevsky, BO Dubrovsky, C Beck, CE Weaver, CE Weaver Jr., CH Lee, CL Kussius, CT Smothers, CT Smothers, E Karakas, E Stastna, EE Baulieu, G Abdrachmanova, GQ Chen, H Havlikova, HR Chang, I Cerny, J Borovska, J Dai, J Zuo, JA Kemp, K Kashiwagi, K Vales, L Nowak, L Rambousek, L Vyklicky Jr., LM Arnostova, LP Wollmuth, M Benveniste, M Hollmann, M Horak, M Korinek, M Park-Chung, M Park-Chung, M Park-Chung, M Petrovic, M Sheng, M Xu, MA Larkin, MA Lomize, MA Lynch, MF Sanner, ML Mayer, MM Zarei, N Kashiwabuchi, NJ Sucher, PA Lapchak, R Kancheva, R Kazi, R Sprengel, RH Evans, S Schreier, SE Murthy, SF Traynelis, SH Mellon, SI Mota   +61 more
core   +1 more source

N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex. [PDF]

Proceedings of the National Academy of Sciences, 1989
Kindling is an animal model of epilepsy and neuronal plasticity produced by periodic electrical stimulation of the brain. Electrophysiologic studies indicate that this phenomenon is associated with increased participation of N-methyl-D-aspartate (NMDA) receptors in excitatory synaptic transmission. Biochemical studies suggest that a change intrinsic to
J.V. Nadler, Geng-Chang Yeh, Douglas W. Bonhaus, James O. McNamara   +3 more
openaire   +3 more sources

In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer’s disease

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory.
Maleeha Waqar, Sidra Batool
doaj   +1 more source

Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties

Nature Communications, 2018
N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg2+ and ...
Laura Fedele, Joseph Newcombe, Maya Topf, Alasdair Gibb, Robert J. Harvey, Trevor G. Smart   +5 more
doaj   +1 more source

GRIN1 Mutations in Early-Onset Epileptic Encephalopathy

Pediatric Neurology Briefs, 2015
Investigators from Yokohama City University and other medical centers in Israel and Japan reported mutations on N-methyl-D-aspartate (NMDA) receptors subunit GRIN1 (GluN1) identified in patients with nonsyndromic intellectual disability and early-onset ...
Wenjuan Chen, Hongjie Yuan
doaj   +1 more source

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Nature Communications, 2020
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa   +11 more
doaj   +1 more source