Results 31 to 40 of about 55,585 (143)
Brazilian Neurosurgery, 2013 Cerebral edema and excitoxicity are well known phenomena and are reported in multiple pathological contexts. Despite that, regarding traumatic brain injury, significant events in incidence and potential clinical consequences, little is known about the ...
José Luís Alves, Anabela Mota Pinto
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Subunit Arrangement in N-Methyl-d-aspartate (NMDA) Receptors [PDF]
Journal of Biological Chemistry, 2010 N-Methyl-d-aspartate (NMDA) receptors, the main mediators of excitatory synaptic transmission, are heterotetrameric receptors. Typically, glycine binding NR1 subunits co-assemble with glutamate binding NR2 subunits to form a functional receptor. Here we have used luminescence resonance energy transfer (LRET) investigations to establish the specific ...
Anu Rambhadran +2 more
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Anti-N-methyl-D-aspartate receptor encephalitis, a diagnosis not to miss
European Journal of Case Reports in Internal Medicine, 2023 Anti-N-methyl-D-aspartate receptor (Anti-NMDAR) encephalitis is a rare autoimmune disease, characterized by the presence of neuropsychiatric symptoms. It is sometimes mistaken for a psychiatric disorder and other times not considered in the differential diagnosis of an encephalitic process.
Tiago Valente +3 more
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Anti-N-methyl-D-aspartate receptor encephalitis: analysis of three cases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Objective To study clinical features, diagnosis, therapy response and prognosis of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Methods Three cases with anti-NMDAR encephalitis were reported.
Hui SU, Rong-fei WANG, Sheng-yuan YU
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Dopamine and N-Methyl-D- Aspartate Receptor Interactions in the Neostriatum [PDF]
Developmental Neuroscience, 1998 This review examines dopamine (DA) and glutamate receptor interactions in the neostriatum (NS) primarily from a neurophysiological perspective. Historically, a clear understanding of the function of DA in the NS has been difficult because it was considered a classical neurotransmitter with either excitatory or inhibitory actions and because many of the
Carlos Cepeda, Michael Levine
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Nature Communications, 2021 N-Methyl-D-aspartate receptors (NMDARs) activation involves closure of the GluN1 and GluN2 subunit ligand binding domains, which is regulated allosterically by the amino-terminal domain (ATD).
Vojtech Vyklicky +3 more
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Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging
Frontiers in Aging Neuroscience, 2010 N-methyl-D-aspartate (NMDA) receptors are present in high density within the cerebral cortex and hippocampus and play an important role in learning and memory.
Brenna L Brim, Siba R Das
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Spermine regulates N-methyl-d-aspartate receptor desensitization
Neuron, 1992 The action of the endogenous polyamine spermine on NMDA-induced responses (in the presence of glycine) was evaluated in cultured spinal cord neurons under voltage- and concentration-clamp conditions. Spermine potentiated NMDA-induced responses in a dose-dependent manner.
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Neural Regeneration ResearchThe involvement of the excitatory amino acids glutamate and aspartate in cerebral ischemia and excitotoxicity is well-documented. Nevertheless, the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely ...
Victoria Jiménez Carretero +4 more
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ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression [PDF]
Frontiers in Molecular Neuroscience, 2017 Since the discovery that a single dose of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, had rapid and long-lasting antidepressant effects, there has been increased interest in using NMDAR modulators in the pharmacotherapy of depression.
Chan, S, Matthews, E, Burnet, P
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