Results 31 to 40 of about 149,284 (337)

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-d-Aspartate Receptors

Journal of Neuroscience, 2013
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS.
S. Paul, J. Doherty, A. Robichaud, Gabriel M. Belfort, B. Chow, R. Hammond, Devon C. Crawford, Andrew J. Linsenbardt, Hong‐Jin Shu, Y. Izumi, S. Mennerick, C. Zorumski   +11 more
semanticscholar   +1 more source

Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease [PDF]

, 2010
Abnormally enhanced N-methyl-D-aspartate (NMDA) receptor function is implicated in Huntington's disease (HD). In this issue of Neuron and a recent issue of Nature Medicine, an abnormal balance between the activity of NMDA receptors at synaptic ...
André, Véronique M., Cepeda, Carlos, Levine, Michael S.   +2 more
core   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model [PDF]

, 2015
Most patients with N-methyl D-aspartate-receptor antibody encephalitis develop seizures but the epileptogenicity of the antibodies has not been investigated in vivo.
Bartram, Julian, Hashemi, Kevan, Lang, Bethan, Stasiak, Lukasz, Upton, A. Louise, Vincent, Angela, Wright, Sukhvir   +6 more
core   +1 more source

Cyclisation of Cell Penetrating PDZ-Binding Peptides Directed to PSD95 [PDF]

, 2019
Excitatory glutamatergic neurotransmission via N-methyl-D-aspartate receptor (NMDAR) is critical for synaptic plasticity and survival of neurons. Excessive NMDAR activity, however can cause excitotoxicity and promote cell death, underlying a potential ...
Al-Nasir, J, Austen, BM, Dabhi, S, Duberly, K, Wijesiriwardana, N   +4 more
core   +2 more sources

Polyglutamine-expanded Huntingtin Promotes Sensitization of N-Methyl-d-aspartate Receptors via Post-synaptic Density 95*

Journal of Biological Chemistry, 2001
Increased glutamate-mediated excitotoxicity seems to play an important role in the pathogenesis of Huntington's disease (Tabrizi, S. J., Cleeter, M. W., Xuereb, J., Taaman, J. W., Cooper, J. M., and Schapira, A. H. (1999)Ann. Neurol. 45, 25–32). However,
Y. Sun, Anneli Savanenin, P. Reddy, Y. Liu   +3 more
semanticscholar   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex. [PDF]

Proceedings of the National Academy of Sciences, 1989
Kindling is an animal model of epilepsy and neuronal plasticity produced by periodic electrical stimulation of the brain. Electrophysiologic studies indicate that this phenomenon is associated with increased participation of N-methyl-D-aspartate (NMDA) receptors in excitatory synaptic transmission. Biochemical studies suggest that a change intrinsic to
J.V. Nadler, Geng-Chang Yeh, Douglas W. Bonhaus, James O. McNamara   +3 more
openaire   +3 more sources

Development and characterization of functional antibodies targeting NMDA receptors

Nature Communications, 2022
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders.
Nami Tajima, Noriko Simorowski, Remy A. Yovanno, Michael C. Regan, Kevin Michalski, Ricardo Gómez, Albert Y. Lau, Hiro Furukawa   +7 more
doaj   +1 more source

Advances and Barriers in Understanding Presynaptic N-Methyl-D-Aspartate Receptors in Spinal Pain Processing

Frontiers in Molecular Neuroscience, 2022
For decades, N-methyl-D-aspartate (NMDA) receptors have been known to play a critical role in the modulation of both acute and chronic pain. Of particular interest are NMDA receptors expressed in the superficial dorsal horn (SDH) of the spinal cord ...
Annemarie Dedek, Annemarie Dedek, Michael E. Hildebrand, Michael E. Hildebrand   +3 more
doaj   +1 more source