Results 161 to 170 of about 454,469 (213)
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Characteristics of Partially Purified Nerve Growth Factor Receptor
Journal of Neurochemistry, 1987Abstract: Receptors for the nerve growth factor protein (NGF) have been isolated from three cell types [embryonic chicken sensory neurons (dorsal root sensory ganglia; DRG), rat pheochromocytoma (PC 12) and human neuroblastoma (LAN‐1) cells] and have been shown to be similar with respect to equilibrium dissociation constants.
R W, Stach, C R, Lyons, J R, Perez-Polo
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Expression of nerve growth factor receptors in cutaneous inflammation
British Journal of Dermatology, 1998Evidence indicates that the neurotrophin nerve growth factor (NGF) is a mediator of cutaneous inflammatory responses. Cellular responses to NGF are facilitated by two receptors called trk A and p75 neurotrophin receptor (p75NTR). In the current study we have investigated the expression of these receptors in lesional and non-lesional skin from patients ...
H A, Bull +3 more
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Journal of Neurochemistry, 1987
Abstract: We have used biologically active derivatives of β‐nerve growth factor (NGF), modified by biotinylation via carboxyl groups, to target the specific binding of liposomes to cultured rat and human tumor cells bearing NGF receptors. Liposomes, to be used for targeting, were prepared by conjugating streptavidin to phospholipid amino groups on ...
M B, Rosenberg +2 more
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Abstract: We have used biologically active derivatives of β‐nerve growth factor (NGF), modified by biotinylation via carboxyl groups, to target the specific binding of liposomes to cultured rat and human tumor cells bearing NGF receptors. Liposomes, to be used for targeting, were prepared by conjugating streptavidin to phospholipid amino groups on ...
M B, Rosenberg +2 more
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Journal of Neuroscience Research, 1992
AbstractGlucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells.
P J, Foreman +3 more
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AbstractGlucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells.
P J, Foreman +3 more
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European Journal of Neuroscience, 1990
AbstractSensory neurons of the adult rat dorsal root ganglion (DRG) can be maintained in culture in the absence of nerve growth factor (NGF). We have thus used dissociated cultures of these neurons to study effects of NGF on the regulation of expression of mRNA encoding the nerve growth factor receptor (NGF‐R).
R. M., Lindsay +6 more
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AbstractSensory neurons of the adult rat dorsal root ganglion (DRG) can be maintained in culture in the absence of nerve growth factor (NGF). We have thus used dissociated cultures of these neurons to study effects of NGF on the regulation of expression of mRNA encoding the nerve growth factor receptor (NGF‐R).
R. M., Lindsay +6 more
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Molecular Brain Research, 1992
The synthesis of nerve growth factor (NGF) and nerve growth factor receptor (NGFR) were studied in a C6 glioma cell line by Northern blot hybridization. In response to a glutamate agonist N-methyl-D-aspartic acid (NMDA), NGF mRNA increased by up to 2-fold after 4-12 h of culture.
T, Amano +5 more
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The synthesis of nerve growth factor (NGF) and nerve growth factor receptor (NGFR) were studied in a C6 glioma cell line by Northern blot hybridization. In response to a glutamate agonist N-methyl-D-aspartic acid (NMDA), NGF mRNA increased by up to 2-fold after 4-12 h of culture.
T, Amano +5 more
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The heterogeneity of nerve growth factor receptors.
Progress in clinical and biological research, 1980Chick embryonic sensory ganglia cells have two specific nerve growth factor receptors, site I and site II receptors, whose binding affinities differ by two orders of magnitude. As judged by both steady state binding and kinetic data, the two receptors behave independently.
A, Sutter +3 more
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The Nerve Growth Factor Receptor: Biochemical and Structural Analysis
1989Publisher Summary This chapter reviews the biochemical characterization of the human nerve growth factor (NGF) receptor and the expression and molecular cloning of the receptor after gene transfer into heterologous cells. It also discusses the structural features of the receptor in relation to its many functional responses.
B L, Hempstead, M V, Chao
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The Structure and Expression of the Nerve Growth Factor Receptors
1990Neurotrophic factors, of the type characterized by nerve growth factor (NGF, Levi-Montalcini, 1987) are synthesized in limiting amounts in, and secreted from, the target cells of the innervated neurons and then carried by retrograde flow from the nerve terminal to the neuronal cell body (Thoenen and Barde, 1980).
Catherine Bitler +5 more
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Nerve growth factor & TrkA as novel therapeutic targets in cancer.
Biochimica et Biophysica Acta, 2016I. Demir +4 more
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