Results 21 to 30 of about 454,469 (213)

Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies

Stem Cells Translational Medicine, 2021
Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate
Kangkang Zha, Yu Yang, Guangzhao Tian, Zhiqiang Sun, Zhen Yang, Xu Li, Xiang Sui, Shuyun Liu, Jinmin Zhao, Quanyi Guo   +9 more
doaj   +1 more source

Regulations of Astrocytic Functions by Endothelins: Roles in the Pathophysiological Responses of Damaged Brains

Journal of Pharmacological Sciences, 2012
The receptors for endothelins (ETs) are classified into the ETA and ETB types. ETB receptors are highly expressed in astrocytes, but pharmacological usages of this receptor are not clarified.
Yutaka Koyama, Shotaro Michinaga
doaj   +1 more source

Nerve growth factor and its receptor in schizophrenia

BBA Clinical, 2014
Promising studies suggest that defects in synaptic plasticity detected in schizophrenia may be linked to neurodevelopmental and neurodegenerative abnormalities and contribute to disease-associated cognitive impairment. We aimed to clarify the role of the synaptic plasticity regulatory proteins, nerve growth factor (NGF) and its receptor (NGFR) in the ...
Zakharyan, Roksana, Atshemyan, Sofi, Gevorgyan, Anaida, Boyajyan, Anna   +3 more
openaire   +2 more sources

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

Journal of Biological Chemistry, 1979
Steady state and kinetic studies on the binding of 125I-beta nerve growth factor (NGF) to single cells from sensory ganglia of 8-day-old chick embryos show two distinct, saturable binding sites with dissociation constants of Kd(I) = 2.3 X 10(-11) M and ...
A. Sutter, R. Riopelle, R. Harris-Warrick, E. Shooter   +3 more
semanticscholar   +1 more source

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

Journal of Neuroscience, 1998
In addition to its role as a survival factor, nerve growth factor (NGF) has been implicated in initiating apoptosis in restricted cell types both during development and after terminal cell differentiation.
S. Yoon, P. Casaccia‐Bonnefil, B. Carter, M. Chao   +3 more
semanticscholar   +1 more source

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

ASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou, Ming Tong, Jean P. Vonsattel, Suzanne M. de la Monte   +3 more
doaj   +1 more source

P75 nerve growth factor receptors modulate development of GnRH neurons and olfactory ensheating cells

Frontiers in Neuroscience, 2013
Temporal and spatial localization of nerve growth factor receptor (p75NGFR) in the developing olfactory system and gonadotropin-releasing hormone-1 (GnRH) system was characterized and its role analyzed using p75NGFR null mice and nasal explants ...
Franca eRaucci, Jean D Tiong, Susan eWray   +2 more
doaj   +1 more source

Nerve Growth Factor Receptors in the Peripubertal Rat Ovary [PDF]

Molecular Endocrinology, 1991
We previously demonstrated that the immature rat ovary synthesizes nerve growth factor (NGF), and that interference of NGF actions by immunoneutralization during neonatal life prevents development of the ovarian sympathetic innervation and delays follicular maturation. Since the actions of NGF are exerted via binding to specific cell surface receptors,
G A, Dissen, D F, Hill, M E, Costa, Y J, Ma, S R, Ojeda   +4 more
openaire   +2 more sources

Recent advances in understanding neurotrophin signaling [version 1; referees: 2 approved]

F1000Research, 2016
The nerve growth factor family of growth factors, collectively known as neurotrophins, are evolutionarily ancient regulators with an enormous range of biological functions.
Mark Bothwell
doaj   +1 more source

Hidden receptors for nerve growth factor in PC12 cells [PDF]

European Journal of Biochemistry, 1983
The binding of nerve growth factor (NGF) to its receptors in PC12 cells was studied in two experimental conditions: (a) cell fixation with paraformaldehyde followed by permeabilization of the plasma membrane with methanol and (b) metabolic poisoning of living cells with sodium azide.
CATTANEO, ANTONINO, BIOCCA S, NASI S, CALISSANO P.   +3 more
openaire   +5 more sources