Results 21 to 30 of about 9,282,759 (299)

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

open access: yesPLoS Biology, 2011
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis   +8 more
doaj   +1 more source

Expression and Function of Nerve Growth Factor and Nerve Growth Factor Receptor on Cultured Keratinocytes

open access: yesJournal of Investigative Dermatology, 1994
Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal keratinocytes express the low-affinity nerve growth factor receptor (NGF-R).
PINCELLI, Carlo   +9 more
openaire   +3 more sources

Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain

open access: yesMolecular Pain, 2017
Sequestration of nerve growth factor has been used successfully in the management of pain in animal models of bone disease and in human osteoarthritis.
Sara Nencini   +5 more
doaj   +1 more source

Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies

open access: yesStem Cells Translational Medicine, 2021
Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate
Kangkang Zha   +9 more
doaj   +1 more source

Regulations of Astrocytic Functions by Endothelins: Roles in the Pathophysiological Responses of Damaged Brains

open access: yesJournal of Pharmacological Sciences, 2012
The receptors for endothelins (ETs) are classified into the ETA and ETB types. ETB receptors are highly expressed in astrocytes, but pharmacological usages of this receptor are not clarified.
Yutaka Koyama, Shotaro Michinaga
doaj   +1 more source

Nerve Growth Factor Receptors in the Peripubertal Rat Ovary [PDF]

open access: yesMolecular Endocrinology, 1991
We previously demonstrated that the immature rat ovary synthesizes nerve growth factor (NGF), and that interference of NGF actions by immunoneutralization during neonatal life prevents development of the ovarian sympathetic innervation and delays follicular maturation. Since the actions of NGF are exerted via binding to specific cell surface receptors,
G A, Dissen   +4 more
openaire   +2 more sources

Nerve growth factor and its receptor in schizophrenia

open access: yesBBA Clinical, 2014
Promising studies suggest that defects in synaptic plasticity detected in schizophrenia may be linked to neurodevelopmental and neurodegenerative abnormalities and contribute to disease-associated cognitive impairment. We aimed to clarify the role of the synaptic plasticity regulatory proteins, nerve growth factor (NGF) and its receptor (NGFR) in the ...
Zakharyan, Roksana   +3 more
openaire   +2 more sources

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

open access: yesASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou   +3 more
doaj   +1 more source

P75 nerve growth factor receptors modulate development of GnRH neurons and olfactory ensheating cells

open access: yesFrontiers in Neuroscience, 2013
Temporal and spatial localization of nerve growth factor receptor (p75NGFR) in the developing olfactory system and gonadotropin-releasing hormone-1 (GnRH) system was characterized and its role analyzed using p75NGFR null mice and nasal explants ...
Franca eRaucci   +2 more
doaj   +1 more source

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

open access: yes, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C.   +5 more
core   +1 more source

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