Results 31 to 40 of about 454,469 (213)

Nerve Growth and Expression of Receptors for Nerve Growth Factor in Tumors of Melanocyte Origin

Journal of Investigative Dermatology, 1991
Nerve growth factor (NGF) stimulates growth and differentiation of sensory and sympathetic neurons. It is not known what role NGF plays in melanoma development, but nevus and malignant melanoma cells express NGF-receptor (NGF-R). We counted nerve fibers within melanocytic nevi, primary cutaneous melanomas, and cutaneous melanoma metastases using a ...
Bröcker, Eva Bettina., Magiera, Heike., Herlyn, Meenhard.   +2 more
openaire   +2 more sources

Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors.

Brain Research. Molecular Brain Research, 2001
In the primary olfactory pathway axons of olfactory neurons (ONs) are accompanied by ensheathing cells (ECs) as the fibres course towards the olfactory bulb. Ensheathing cells are thought to play an important role in promoting and guiding olfactory axons
E. Woodhall, A. West, M. Chuah
semanticscholar   +1 more source

Neuroimmune communication in allergic rhinitis

Frontiers in Neurology, 2023
The prevalence rate of allergic rhinitis (AR) is high worldwide. The inhalation of allergens induces AR, which is an immunoglobulin E-mediated and type 2 inflammation-driven disease.
Yi Zhou, Yi Zhou, Ru Chen, Lili Kong, Lili Kong, Yaoyao Sun, Jing Deng, Jing Deng   +7 more
doaj   +1 more source

Binding of Nerve Growth Factor Receptor in Sympathetic Ganglia [PDF]

Proceedings of the National Academy of Sciences, 1973
125 I-Labeled nerve growth factor binds to membrane preparations from superior cervical ganglia of rabbit in a specific fashion indicative of an interaction with the physiological receptor. Of various tissues examined, binding was observed only in the superior cervical ganglia, a presumed target organ of nerve growth factor ...
S P, Banerjee, S H, Snyder, P, Cuatrecasas, L A, Greene   +3 more
openaire   +2 more sources

Distribution of neuronal receptors for nerve growth factor in the rat [PDF]

The Journal of Neuroscience, 1986
To survey the distribution of neuronal receptors for NGF, sections of the rat brain, spinal cord, and peripheral ganglia were incubated in vitro with radioiodinated NGF and examined by autoradiography. NGF binds selectively with high affinity to most sympathetic neurons and many primary sensory neurons together with their intraspinal or intramedullary ...
P M, Richardson, V M, Issa, R J, Riopelle   +2 more
openaire   +2 more sources

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

Journal of Biological Chemistry, 1984
Association of 125I-nerve growth factor (NGF) with PC12 pheochromocytoma cells was studied. Surface-bound and internalized NGF were distinguished by differential release of the former at low pH, high salt.
P. Bernd, L. Greene
semanticscholar   +1 more source

Ethanol Neurotoxicity in the Developing Cerebellum: Underlying Mechanisms and Implications

Brain Sciences, 2013
Ethanol is the main constituent of alcoholic beverages that exerts toxicity to neuronal development. Ethanol affects synaptogenesis and prevents proper brain development.
Ambrish Kumar, Holly A. LaVoie, Donald J. DiPette, Ugra S. Singh   +3 more
doaj   +1 more source

Full-length optic nerve regeneration in the absence of genetic manipulations

JCI Insight, 2023
The inability of mature retinal ganglion cells (RGCs) to regenerate axons after optic nerve injury can be partially reversed by manipulating cell-autonomous and/or -nonautonomous factors.
Qian Feng, Kimberly A. Wong, Larry I. Benowitz   +2 more
doaj   +1 more source

Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction

Cells, 2021
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and results in severe neurodegeneration and progressive cognitive decline. Neurotrophins are growth factors involved in the development and survival of neurons, but also in underlying
Märta Dahlström, Nather Madjid, Gunnar Nordvall, Magnus M. Halldin, Erika Vazquez-Juarez, Maria Lindskog, Johan Sandin, Bengt Winblad, Maria Eriksdotter, Pontus Forsell   +9 more
doaj   +1 more source

Neurotrophic signaling in liver cancers: mechanisms and potential therapeutic targets [PDF]

Exploration of Digestive Diseases
Recent studies demonstrate that peripheral innervation and Schwann cells (SCs) activity within the tumor microenvironment (TME) have a significant influence on liver cancer, specifically hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (
Lorenzo Mainardi, Fabio Marra, Chiara Raggi   +2 more
doaj   +1 more source