Results 51 to 60 of about 9,282,759 (299)

Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study

Revstat Statistical Journal, 2006
In this article, we analyze time dependent protein expression data obtained from a proteome study of a neuroblastoma cell line. Neuroblastoma are common solid tumors which occur in early childhood.
Klaus Jung , Ali Gannoun , Barbara Sitek , Ognjan Apostolov , Alexander Schramm , Helmut E. Meyer , Kai Stühler , Wolfgang Urfer   +7 more
doaj   +1 more source

Distribution of neuronal receptors for nerve growth factor in the rat [PDF]

The Journal of Neuroscience, 1986
To survey the distribution of neuronal receptors for NGF, sections of the rat brain, spinal cord, and peripheral ganglia were incubated in vitro with radioiodinated NGF and examined by autoradiography. NGF binds selectively with high affinity to most sympathetic neurons and many primary sensory neurons together with their intraspinal or intramedullary ...
P M, Richardson, V M, Issa, R J, Riopelle   +2 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An organized 3D in vitro model for peripheral nerve studies [PDF]

, 2013
Three-dimensional cell cultures have been proposed to address the limitations in two-dimensional cell cultures (i.e. lack of relevant architectural features) and very few have developed 3D cell culture methods for peripheral nerve studies. Therefore, the
Daud, Muhammad Fauzi
core   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury [PDF]

, 2006
Neuregulin/erbB signaling is critically required for survival and proliferation of Schwann cells as well as for establishing correct myelin thickness of peripheral nerves during development.
Atanasoski, Suzana, Birchmeier, C., Garratt, Alistair N., Birchmeier, Carmen, Suter, U., Sirkowski, E., Scherer, Steven S., Atanasoski, S., Suter, Ueli, Scherer, S.S., Sirkowski, Erich, Garratt, A.N., S. Atanasoski, Leone, Dino, Leone, D.   +14 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.

PLoS ONE, 2008
BackgroundSelective serotonin reuptake inhibitors (SSRIs) have been widely used and are a major therapeutic advance in psychopharmacology. However, their pharmacology is quite heterogeneous.
Tomoko Nishimura, Tamaki Ishima, Masaomi Iyo, Kenji Hashimoto   +3 more
doaj   +1 more source

The relationship between gonadotropin releasing hormone and ovulation inducing factor/nerve growth factor receptors in the hypothalamus of the llama

Reproductive Biology and Endocrinology, 2018
Background A molecule identical to nerve growth factor, with ovulation-inducing properties has been discovered in the seminal plasma of South American camelids (ovulation-inducing factor/nerve growth factor; OIF/NGF).
Rodrigo A. Carrasco, Jaswant Singh, Gregg P. Adams   +2 more
doaj   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A, Adriaens, M.E., Adriaens, Michiel E., Kolch, W, Amelie Gormand, Adriaens, ME, Gormand, A., Sturm, OE, David R Gilbert, Richard J Orton, Walter Kolch, Orton, RJ, Orton, Richard J., Oliver E Sturm, Gilbert, D, Gilbert, David R., Michiel Adriaens, M.E., Michiel E Adriaens, Orton, R.J., Kolch, Walter, Kolch, W., Gilbert, D.R., Sturm, O.E., Sturm, Oliver E., et al., Gormand, Amelie, Gormand, Amelie,, Lund University.   +27 more
core   +1 more source