Results 61 to 70 of about 454,469 (213)

Neurotrophins and Neuropathic Pain: Role in Pathobiology

Molecules, 2015
Neurotrophins (NTs) belong to a family of trophic factors that regulate the survival, growth and programmed cell death of neurons. In mammals, there are four structurally and functionally related NT proteins, viz. nerve growth factor (NGF), brain-derived
Nemat Khan, Maree T. Smith
doaj   +1 more source

Endothelin systems in the brain: involvement in pathophysiological responses of damaged nerve tissues

Biomolecular Concepts, 2013
In addition to their potent vasoconstriction effects, endothelins (ETs) show multiple actions in various tissues including the brain. The brain contains high levels of ETs, and their production is stimulated in many brain disorders. Accumulating evidence
Koyama Yutaka
doaj   +1 more source

Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

eLife
Ligands such as insulin, epidermal growth factor, platelet-derived growth factor, and nerve growth factor (NGF) initiate signals at the cell membrane by binding to receptor tyrosine kinases (RTKs).
Duk-Su Koh, Anastasiia Stratiievska, Subhashis Jana, Shauna C Otto, Teresa M Swanson, Anthony Nhim, Sara Carlson, Marium Raza, Ligia Araujo Naves, Eric N Senning, Ryan A Mehl, Sharona E Gordon   +11 more
doaj   +1 more source

Nerve Growth Factor from Cobra Venom Inhibits the Growth of Ehrlich Tumor in Mice

Toxins, 2014
The effects of nerve growth factor (NGF) from cobra venom (cvNGF) on growth of Ehrlich ascites carcinoma (EAC) cells inoculated subcutaneously in mice have been studied.
Alexey V. Osipov, Tatiana I. Terpinskaya, Elena V. Kryukova, Vladimir S. Ulaschik, Lubov V. Paulovets, Elena A. Petrova, Ekaterina V. Blagun, Vladislav G. Starkov, Yuri N. Utkin   +8 more
doaj   +1 more source

Neurotrophic factors and their effects in the treatment of multiple sclerosis

Advanced Biomedical Research, 2015
Neurotrophins are small molecules of polypeptides, which include nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor (GDNF) family ligands, and neuropoietic cytokines. These factors have an important role in neural regeneration,
Shahnaz Razavi, Ghasemi Nazem, Mohammad Mardani, Ebrahim Esfandiari, Hossein Salehi, Sayyed Hamid Zarkesh Esfahani   +5 more
doaj   +1 more source

The evolution of nerve growth factor inhibition in clinical medicine

Nature Reviews Rheumatology, 2020
B. Wise, M. Seidel, N. Lane
semanticscholar   +1 more source

Axonal Regeneration across Long Gaps in Silicone Chambers Filled with Schwann Cells Overexpressing High Molecular Weight FGF-2

Cell Transplantation, 2003
Basic fibroblast growth factor (FGF-2) has been shown to enhance the survival and neurite extension of various types of neurons including spinal ganglion neurons.
M. Timmer, S. Robben, F. Müller-Ostermeyer, G. Nikkhah, C. Grothe DR.   +4 more
doaj   +1 more source

NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin

Neurobiology of Disease, 1994
Nerve growth factor (NGF) acts through trkA receptors to serve as a trophic factor for cholinergic neurones in the medial septal nucleus (MSN) and vertical limb of the diagonal band (VDB).
David M. Holtzman, Joshua Kilbridge, David S. Bredt, Stephen M. Black, Yiwen Li, Douglas O. Clary, Louis F. Reichardt, William C. Mobley   +7 more
doaj   +1 more source

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

Journal of Biological Chemistry, 1994
Nerve growth factor (NGF) binds to two cell surface receptors, p140trk and p75NGFR, which are both expressed in responsive sensory, sympathetic, and basal forebrain cholinergic neurons.
D. Mahadeo, Leon Kaplan, M. Chao, B. Hempstead   +3 more
semanticscholar   +1 more source

Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling

Scientific Reports, 2017
Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors.
Mayu Kasubuchi, Keita Watanabe, Kanako Hirano, Daisuke Inoue, Xuan Li, Kazuya Terasawa, Morichika Konishi, Nobuyuki Itoh, Ikuo Kimura   +8 more
doaj   +1 more source