Results 81 to 90 of about 224,411 (312)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Nerve Growth Factor Receptors in the Peripubertal Rat Ovary [PDF]

Molecular Endocrinology, 1991
We previously demonstrated that the immature rat ovary synthesizes nerve growth factor (NGF), and that interference of NGF actions by immunoneutralization during neonatal life prevents development of the ovarian sympathetic innervation and delays follicular maturation. Since the actions of NGF are exerted via binding to specific cell surface receptors,
G A, Dissen, D F, Hill, M E, Costa, Y J, Ma, S R, Ojeda   +4 more
openaire   +2 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player

Frontiers in Molecular Neuroscience, 2014
The classic neurotrophins Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF) and Neurotrophins NT-3 and NT-4 are well known to regulate various aspects of neuronal differentiation, survival and growth.
Rachel eUren, Ann eTurnley
doaj   +1 more source

Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth. [PDF]

, 1987
Neuronal responses to extracellular matrix (ECM) constituents are likely to play an important role in nervous system development and regeneration. We have studied the interactions of a neuron-like rat pheochromocytoma cell line, PC12, with ECM protein ...
Damsky, CH, Reichardt, LF, Tomaselli, KJ
core  

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit, A Romero, A Serrano, A Strasser, AA Genazzani, AJ Shaywitz, Andreas Breit, AS Kirshenbaum, B Fioravanti, B Knoll, B Zimmerman, BD Hudson, C Abbadie, C Gaudioso, CH Wang, DA Taylor, DB Wainscott, E Bullitt, E Grazzini, E Utreras, EJ Vallender, ES Burstein, F Jow, FA White, FA White, Franziska Petermann, G Buchwalter, G Kendall, GA Jamieson Jr, H Chen, H Jung, H Jung, H Subramanian, Hans Jürgen Solinski, HB McIlvain, HJ Solinski, Ingrid Boekhoff, J Li, JG Jackson, JH Sun, JJ Moore Jr, K Rothe, K Tatemoto, Kathrin Rothe, KL Pierce, L Hao, L Jenkins, LM Boland, M Brinkmann, N Eijkelkamp, N Katayama, N Kerr, OM Andrisani, P Kunapuli, P Sikand, PC Francel, PM Lembo, PS Puttfarcken, R Maldonado, RD Groth, RD Groth, RJ Davis, Roland Seifert, S Bhangoo, S Dolan, SF Fan, SK Bhangoo, SN Fatakia, SW Ko, Thomas Gudermann, V Baubet, VS Seybold, X Dong, Y Li   +73 more
core   +3 more sources

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Targeting nerve growth factor: an Achilles’ heel for tumors?

Journal for ImmunoTherapy of Cancer
A tumor’s ability to attract innervation is a critical factor in tumor progression and immune escape, with the sympathetic nervous system playing a major role.
Elizabeth Repasky, Hemn Mohammadpour
doaj   +1 more source

Modeling Glioma Growth and Invasion in Drosophila melanogaster

Neoplasia: An International Journal for Oncology Research, 2009
Glioblastoma is the most common and most malignant intrinsic human brain tumor, characterized by extensive invasion and proliferation of glial (astrocytic) tumor cells, frequent activation of tyrosine kinase receptor signaling pathways, relative ...
Hanna Teresa Witte, Astrid Jeibmann, Christian Klämbt, Werner Paulus   +3 more
doaj   +1 more source

Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 2001
Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core