Results 81 to 90 of about 521,660 (353)

The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]

, 2018
AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G., Coskun, E., Erdoğan, Çağdaş, Ozkul, A., Sahin, B., Topcu, A., Yilmaz, A.   +6 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia

Journal of Pain Research, 2013
Satoshi Mizobuchi,1* Hirotaka Kanzaki,1–3* Hiroki Omiya,1 Yoshikazu Matsuoka,1 Norihiko Obata,1 Ryuji Kaku,1 Hirochika Nakajima,1 Mamoru Ouchida,2 Kiyoshi Morita11Department of Anesthesiology and Resuscitology, 2Department of Molecular Genetics,
Mizobuchi S, Kanzaki H, Omiya H, Matsuoka Y, Obata N, Kaku R, Nakajima H, Ouchida M, Morita K   +8 more
doaj  

Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study

Revstat Statistical Journal, 2006
In this article, we analyze time dependent protein expression data obtained from a proteome study of a neuroblastoma cell line. Neuroblastoma are common solid tumors which occur in early childhood.
Klaus Jung , Ali Gannoun , Barbara Sitek , Ognjan Apostolov , Alexander Schramm , Helmut E. Meyer , Kai Stühler , Wolfgang Urfer   +7 more
doaj   +1 more source

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The relationship between gonadotropin releasing hormone and ovulation inducing factor/nerve growth factor receptors in the hypothalamus of the llama

Reproductive Biology and Endocrinology, 2018
Background A molecule identical to nerve growth factor, with ovulation-inducing properties has been discovered in the seminal plasma of South American camelids (ovulation-inducing factor/nerve growth factor; OIF/NGF).
Rodrigo A. Carrasco, Jaswant Singh, Gregg P. Adams   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effects of castration on the immunoreactivity to NGF, BDNF and their receptors in the pelvic ganglia of the male rat

European Journal of Histochemistry, 2009
Nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) and are members of the neurotrophin family, a family of neurotrophic factors that also includes neurotrophin (NT) 3 and NT4/5.
C Squillacioti, A De Luca, G Paino, N Mirabella   +3 more
doaj   +1 more source

Version control of pathway models using XML patches [PDF]

, 2009
<p>Background: Computational modelling has become an important tool in understanding biological systems such as signalling pathways. With an increase in size complexity of models comes a need for techniques to manage model versions and their ...
Orton, R., Saffrey, P.
core   +4 more sources